Metabolic Proccesses (phase I And Phase II)

Question 1

What does phase 1 metabolic processes include

Answer 1

Reduction - carbonyl compounds, nitrogen compounds, sulfoxides
Hydrolysis - esters and amides, epoxides
Decarboxylation - amine acids

Question 2

Explain the metabolic reduction in carbonyl compounds

Answer 2

Question 3

Explain metabolic reduction of nitro compound

Answer 3

Question 4

Explain metabolic reduction of sulfoxides

Answer 4

Question 5

Explain hydrolysis

Answer 5

Question 6

Explain methylation

Answer 6

Question 7

Most of the Phase 2 are what reactions ?

Answer 7

Conjugated reaction catalyzed by transferases enzymes resulting in inactive conjugate

Question 8

Which conjugates are the most common

Answer 8

Glucuronic acid

Question 9

How is glucuronic acid attached to the drug

Answer 9

Question 10

How is the resulting conjugate excreted

Answer 10

Question 11

What are the two types of phase II reactions

Answer 11

Removal
Inactivation

Question 12

Explain removal

Answer 12

Question 13

Why is the most common conjugative pathway in drug metabolism is Glucuronidation

Answer 13

Question 14

What is the Glucuronidation products

Answer 14

Question 15

Explain drug-drug interaction with examples

Answer 15

Question 16

Explain drug-food interactions

Answer 16

Question 17

Give example of drug food interaction

Answer 17

Question 18

Explain inactivation

Answer 18