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Medicinal Chemistry > NSAIDs 3 > Flashcards

NSAIDs 3 Flashcards

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1
Q

List the arylpropionic acids

A

Ibuprofen
Fenoprofen
Ketoprofen
Naproxen

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2
Q

One of the most widely used NSAIDs in anylpropionic acid

A

Naproxen

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3
Q

Explain potency of ibuprofen

A
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4
Q

What enhances anti-inflammatory actions and reduces many side effects in ibuprofen

A
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5
Q

What is better ibuprofen or ibufenac

A
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6
Q

Explain the stereochemistry

A
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7
Q

Explain the metabolism of ibuprofen

A
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8
Q

Explain the mode of action of ibuprofen

A
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9
Q

Why can’t ibuprofen and aspirin be used together

A

They work on the same active site

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10
Q

What is Aryl anthranilic acids (fenamates)

A
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11
Q

What are the side effects of aryl anthranilic acids

A
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12
Q

Explain the SAR of aryl anthranilic acid

A
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13
Q

Why is meclofenamic acid 25x more anti inflammatory than mefenamic acid

A

Meclofenomic acid has chlorine in ortho position so no free rotation

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14
Q

What is the drug interaction of aryl anthranilic acid

A

Oral anti-coagulants and aspirin

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15
Q

Aryl anthranilic acid is short term relief of what

A
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16
Q

List the types of oxicams

A

Piroxicam
Meloxicam

17
Q

What are oxicams

A
18
Q

Explain the potency and inhibition of oxicams

A
19
Q

What is the major side effect of oxicams

A

GI side effects

20
Q

Oxicams are what type of compounds

A

Acidic pKa= 4-6

21
Q

Why are N-heterocyclic carboxamides are more acidic

A
22
Q

Explain meloxicam

A
23
Q

Why were selective COX 2 inhibitors developed

A

To over come GI side effects

24
Q

What was produced for the prevention of NSAIDs induced gastric ulcers

A
25
Q

How is coxib selective to COX2

A
26
Q

What are selective COX2 inhibitors used for

A
27
Q

Selective COX inhibitors are what type of series of inhibitors

A

Tricyclic

28
Q

What is the optimum for selectivity of COX2 inhibitors

A
29
Q

What is a disadvantage of COX2 inhibitors

A
30
Q

Explain etoricoxin

A

Medicinal Chemistry (15 decks)

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