PHYS 1 Male reproductive physiology Flashcards
genetic sex? determined by?
5 weeks? 6-7? 9?
gonadal sex?
phenotypic sex?
gonadotropin secretion over lifetime
which is higher when?
puberty initiated by?
these cause what secretion?
GnRH analogue administered intermittently then?
if long acting?
CNS and nutritional status may alter what?
what else?
(2)
the molecule. highest when?
Anatomy of male repro tract
testes- functions? (2)
scrotum- function?
epididymis- function?
anat of male repro tract
vas deferens- functions (2)
seminal visseicles- functions?
prostate gland- functions?
anat of male repro tract
seminiferous tubule- epithelium formed by? with? other cells present? where?
Leydig cells- are where?
adult testis- mainly what structures?
General functions of sertoli/leydig cells
sertoli- (3)
leydig- (1)
testes secrete what male sex hormones?
(3)
most abundant?
some tissues this is converted to?
Testosterone (_)
synthesized and secreted by?
testes lack?
which means?
they do have?
which does what? end product is? not? like in?
Testosterone is concentrated where? by?
more on T
active in all tissues?
in some tissues? like in?
what enzyme converts to this?
circulating T bound to?
Leydig cells are main what cells in testis
get cholesterol from?
store it as?
free cholesterol generated by?
cholesterol then transferred to? via?
cholesterol then converted to?
production of estrogen in the male
how much?
where is it high?
source is what cells? (product of?)
potential important role in what process?
large amounts formed from what (2) in other tissues especially?
biosynthetic pathway of androgens
mitochondrial- rate-limiting step? enzyme?
then what?
so primary endocrine cell of testis?
doesnt make much what?
T diffues into?
what stimulates conversion of cholesterol to pregnenolone? plus rate?
what two ways does it promote pregnenolone synthesis?
enzyme rate limiting also called?
T production
begins when?
androgens bind what receptors?
found in what tissues?
AR in females?
type of receptor?
DHT production
binds what receptor? but?
important role in?
deficiency in what enzyme results in what?
5a-reductase converts T to DHT
fates of T
enters peripheral circ it reaches what with proteins?
% bound/unbound?
excreted primarily where?
mostly as?
remainder as?
T action during fetal development
present at what month?
presence or absence determines?
fetal actions: (2)
problem in one?
T action at puberty?
(7) think about it
specific actions of DHT
one big one?????
then (3)
due to this what treatment for what problems?
androgenic actions
(4)
regulation of differentiation of?
stim what?
maintenance of? (2)
anabolic actions of androgens?
(7)
stim synthesis of?
secretion of?
stim what growth?
maintenance of?
behavior?
androgen and anabolic acions of androgens
think of some be smart about it?
BPH?
what age do a majority have it?
classic signs and symptoms?
important!!!!
what is high/low?
intracellular mechanism of action of T (non nuclear receptor)
what two cells? what receptors? what pathway?
result in?
sertoli cells and T
what will stim sertoli cells? this causes secretion of? into?
this causes what to happen?
sertoli cells
3 main. type of functions (3 classes)
s- maintain?
e- production of? release of?
en- expression of? production of? create what?
this regulates?
