EMB 1 Development of the Genital System Flashcards
when does sexual differentiation begin?
genitalia recognized when?
phenotypic differentiation completes?
week 5
gonads?
within epiblasts?
end up where? after?
migrate up what to enter?
indifferent gonad wk 6
what cells support the primordial germ cells?
in males? females?
development of genital ducts
(2)
form in what?
M- part of what development? will form? (4)
P- will form?
ovary and testis
sexual dimorphism is dependent on? but also?
what gene? on what chromosome?
gonad type in genes determines what development?
absence of SRY?
genes for female development?
The testis
what gene? also called?
present where? active from what time?
expressed in what cells?
up/down regulates what?
what cells surround primordial germ cells? organize?
intertubular cells differentiate into? recruited by?
pictures.
somatic support cells interact with what?
what happens to paramesonephric duct?
paramesenephric duct in males
what cells/gene?
will transcribe what? which releases what?
causes? when?
remnants? (2)
Mesonephric duct development
testosterone from where drives ducts to form:
(4)
paramesonephric duct gone when?
hormonal control of male differentiation
what two cells important?
s- will release what? (2) each does what?
l- subsets? (2)
F- releases? (2) each does what? when is t released? driven by what?
A- release what? does what?
what buds from intermediated mesoderm of urogenital ridge (also called)?
what buds from endoderm of urogenital sinus? what area? what week?
comes from endodermal buds?
development of external genitalia
beginning with?
what three structures?
each comes from?
U- opens what? to what?
G- remnants of? where?
gt- covered by? is what? where?
development of male external genitalia
6-8th week?
what drives lengthening and growth of genital tubercle?
fusion of labioscrotal swellings?
urethra closed by wheN?
testis descent
pictures
what connects what to what?
what starts forming? what shortens? pulling what?
suspensory?
gubernaculum does what?
clinical urethral considerations?
(2)
Hypospadias is a congenital disorder of the urethra where the urinary opening is not at the usual location on the head of the penis.
Epispadias is a rare congenital (present at birth) abnormality that involves the opening of the urethra (the tube from which urine exit the bladder). In boys with epispadias, the urethra opens in top of the penis rather than the tip
the ovary
what is not present? this means what isnt released? so what will remain? this will become what? (3)
what other gene is expressed? what is released that suppresses SOX-9? this does what?
primordial germ cells differentiate into?
these then od what and differentiate into?
somatic cells? differentiate into?
follicle cells do what?
Paramesonephric ducts? mesonephric ducts?
uterus formation
what weeks?
what form the uterus?
uterine tubes are what?
sinuvaginal bulb?
uterus anomalies
term for double?
what fucked up?
probably the paramesonephric ducts fusing to form the uterus
vagina formation
what germ layer?
problems with formation? what causes?
female external genitalia development
phallic segment of urogenital sinus
what 3 things?
female external genitalia development
what differs from males?
what structure may come from what?
glans plate may be going to glans clitoris
formation of broad ligament
fusion of what brings what within pelvic cavity?
covered by?
upon completion of uterus and oviduct formation what happens? this forms?
Round ligaments
(2)
connects what to what?
comes from?
round ligament of ovary may be ovarian ligament
disorders of sex development
(DSD) or (______)
what is atypical?
46 XY DSDs
sex?
what is characteristic?
causes?
(4)
Androgen insensitivity syndrome
male or female?
common cause?
type of inheritance?
will have what but no? what may be high?
puberty?
produce what so what is suppressed? uterus/vagina?
testes found where?
increased risk of?
5 a-reductase deficiency
male or female DSD?
genotype?
inheritance?
whats normal?
characteristic?
female DSDs
what genotype?
has what?
fetus produces?
what might you see of female external genitalia?
most common cause of female sexual ambiguity?
mutations in what?
true intersexuality also called?
have what?
external genitalia? usually have?
causes? (3)
true sex?
