phosphoglucomutase (PGlucM) Flashcards

1
Q

What type of mechanism?

A

double SN2, adding a Pi to position 1….
Also has a substrate flip similar to aconitase., 180 degree reorientation.
Substrate now flipped around and can remove Pi from C6.

highly reversible, interconverion between G6P and G1P

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2
Q

PGlucM structure

A

monomeric,
active site is located at the bottom of a vry deep crevice…

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3
Q

key serine

A

the phosphate located on this serine is mechanistic, because it is the one being transferred in the mechanism.

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4
Q
A
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