Pharmacy

Question 1

What is First-pass metabolism?

Answer 1

First metabolism in the liver, decreasing the amount that reaches the brain or other organs

Question 2

What is MOA of montelukast?

Answer 2

Leukotriene receptor antagonist

Question 3

What medication for asthma has the action of causing smooth muscle relaxation by inhibiting phosphodiesterase?

Answer 3

theophylline

Question 4

ACE-inhibitors are associated with what fetal abnormalities?

Answer 4

1st trimester - cardiovascular and neural tube defects
2nd/3rd trimester - renal anomalies, oligo, IUFD, renal failure

Question 5

What is the difference between SJS and TEN?

Answer 5

SJS <10% epidermal detachment
TEN >30% detachment

Question 6

How is phenobarbitol used in hyperbilirubinemia?

Answer 6

Increases hepatic glucuronyl transferase activity and conjugation of bilirubin, enhances hepatic uptake of bilirubin

Question 7

Treatment with erythromycin or azithromycin in young infants for postexposure prophylaxis or treatment of pertussis is associated with what?

Answer 7

infantile hypertrophic pyloric stenosis

Question 8

Which LABA should be used in conjunction with ICS for SMART asthma therapy?

Answer 8

Formoterol - rapid onset of action in compared to salmeterol

Question 9

What is the timeline for DRESS?

Answer 9

Most reactions are between 2-6 weeks after starting the drug, but can be up to 12 weeks