GI

Question 1

What is the Marsh scale used for?

Answer 1

Biopsy grade for celiac disease - Type 1 - intraepithelial lymphocytes. Type 2 - IELs and crypt hypoplasia. Type 3 - Type 2 + villous atrophy

Question 2

What causes hepatotoxicity after acetaminophen ingestion?

Answer 2

reactive metabolite N-acetyl-p-benzoquinon imine (NAPQI) metabolized by P-450 enzymes –> this normally combines with glutathione to turn into a harmless conjugate. If glutathione stores are depleted, the reactive metabolite causes toxicity

Question 3

What testicular problem is pain relieved with elevation of the testes?

Answer 3

epididymitis - Prehn sign

Question 4

What is the cutaneous finding of celiac disease?

Answer 4

dermatitis herpetiformis

Question 5

What other abnormalities are associated with Prune belly (Eagle-Barrett syndrome)?

Answer 5

bilateral undescended testes and urinary tract abnormalities (hydronephrosis)

Question 6

What type of anemia can be seen with celiac disease?

Answer 6

iron deficiency anemia

Question 7

What is Peutz-Jeghers?

Answer 7

hamartomatous polyps in GI tract, freckling of lips

Question 8

What is side effect of long-term PPI use?

Answer 8

c-diff diarrhea

Question 9

What are the two types of autoimmune hepatitis?

Answer 9

Type 1: 10-20 years old, ANA and anti-smooth muscle antibodies usually positive
Type 2: younger, more severe, anti-liver kidney microsomal antibody positive

Question 10

What gene mutation is the cause of Alagille syndrome?

Answer 10

JAG 1

Question 11

What gene mutation is strongly associated with Crohn disease?

Answer 11

NOD2

Question 12

Findings of Behcet disease?

Answer 12

aphthous ulcers, erythema nodosum or pustular eruption, eye findings (uveitis or vasculitis), and pathergy

Question 13

What GI disorders can you see Erythema nodosum?

Answer 13

behcet (Technically vasculitis), and Crohn disease

Question 14

What are non-diarrhea symptoms of Crohn disease?

Answer 14

Erythema nodosum, aphthous ulcers, cheilitis, glossitis