Pharmacotherapy of Sleep Flashcards

1
Q

what is 1st line treatment of insomnia

A

non-pharm/sleep hygiene

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2
Q

what drug class is commonly used for insomnia

A

z-hypnotics and benzos

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3
Q

what dose of zolpidem in women and elderly

A

5mg

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4
Q

what z hypnotic has a metallic taste side effect

A

eszopiclone

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5
Q

what are side effects of zaleplon

A

odd sleep behaviors
potential for misuse

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6
Q

what are the 2 melatonin receptor agonists

A

ramelteon
tasimelteon

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7
Q

ramelteon side effects

A

GI upset
next day somnolence
prolactinemia
CI with fluvoxamine

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8
Q

what is tasimelteon typically reserved for

A

non 24 hr sleep wake disorder in blind adults

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9
Q

what are orexin receptor antagonists CI in

A

narcolepsy

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10
Q

what are the orexin drugs

A

suvorexant
lemborexant
daridorexant

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11
Q

what antidepressants can be used in sleep aid

A

doxepin
mirtazepine
quetiapine
trazodone

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12
Q

what are the side effects of doxepin

A

anticholinergic SEs

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13
Q

what is the dose of mirtazepine for sleep

A

7-15mg at bedtime

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14
Q

what is the major side effect of mirtazepine

A

weight gain

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15
Q

how to treat sleep apnea

A

weight loss, smoking cessation, avoid alcohol, side sleep, and CPAP

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16
Q

what meds can help with EDS in sleep apnea

A

modafinil or armodafinil

17
Q

what drugs treat cataplexy

A

sodium oxybate
xywave
Lumryz

18
Q

sodium content of sodium oxybate

A

high sodium

19
Q

sodium content of xywave

A

lower sodium

20
Q

age requirements of xywave

A

adults and kids 7+

21
Q

sodium content of lumryz

A

high sodium

22
Q

age requirements of lumryz

A

adults only and once nightly

23
Q

what does pitolisant treat

24
Q

what is CI with pitolisant

A

hepatic impairment

25
what does solriamfetol treat
EDS
26
what is a major SE of solriamfetol
HR and BP increase and uncontrolled psychosis
27
what are the drugs of choice with shift work
modafinil and armodafinil
28
what is first line for restless leg syndrome
gabapentin encarbil
29
what is second line for restless leg syndrome
pramipexole or ropinirole