opthamology Flashcards

1
Q

what is the main difference between open-angle and close-angle glaucoma

A

open-angle is where the drainage canal is obstructed and close-angle is where pressure pushes against cornea

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2
Q

what class of drugs is first line for open-angle glaucoma

A

prostaglandin analogs, beta blockers

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3
Q

what is the MOA of prostaglandin analogs

A

increase aqueous humor outflow

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4
Q

prostaglandin analog dosing

A

1 drop QHS (reduces IOP by 30%)

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5
Q

prostaglandin analog warnings

A

-darkening of iris, skin, and eyelashes
-increase in eyelash length and number

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6
Q

prostaglandin side effects

A

-blurred vision
-stinging
-increased pigmentation
-eyelash thickening
-light sensitivity
-foreign body sensation

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7
Q

Bimatoprost class and brand

A

-prostaglandin analog
-Lumigan
-Latisse (eyelash hypotrichosis)

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8
Q

Travoprost class and brand

A

-prostaglandin analogs
-travatan Z, travatan

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9
Q

Latanoprost class and brand

A

-prostaglandin
-xalatan, xelpros

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10
Q

Tafluprost class and brand

A

-prostaglandin
-zioptan

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11
Q

Beta-blockers MOA

A

reduce aqueous humor production

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12
Q

beta-blocker dosing

A

1 drop daily or BID (reduces IOP 20-30%)

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13
Q

beta-blocker contraindications

A

-sinus bradycardia
-2nd or 3rd degree heart block
-cardiogenic shock
-uncompensated cardiac failure
-bronchospastic disease

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14
Q

beta blocker side effects

A

-stinging
-blurred vision
-bradycardia
-breathing problems
-hypotension
-dizziness
-fatigue
-impotence

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15
Q

timolol class and brand

A

beta blocker
timoptic, timoptic-XE, istalol

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16
Q

carteolol class and brand

A

beta blocker
no brand

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17
Q

levobunolol class and brand

A

beta blockers
betagan

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18
Q

betaxolol class and brand

A

beta blocker
betoptic S

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19
Q

alpha-2 agonists moa

A

increase aqueous humor outflow AND reduce aqueous humor production

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20
Q

alpha-2 agonists dosing

A

1 drop TID (reduce IOP 25%)

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21
Q

alpha-2 agonists contraindications and warnings

A

CNS depression

22
Q

alpha-2 agonists side effects

A

-dry eyes
-xerostomia
-blurry vision
-conjunctival hyperemia
-sedation
-confusion

23
Q

brimonidine class and brand

A

alpha 2 agonists
alphagan P
lumify (OTC redness of eye)

24
Q

brimonidine + timolol class and brand

A

alpha 2 agonists
combigan

25
brimonidine + brinzolamide class and brand
alpha 2 agonists simbrinza
26
Aprachlonidine class and brand
alpha 2 agonists lopidine
27
carbonic anhydrase inhibitors MOA
reduce aqueous humor production
28
carbonic anhydrase inhibitor dosing
1 drop TID (reduce IOP by 15-20%) 50-100mg PO 2-3 times daily
29
carbonic anhydrase inhibitor warnings
sulfonamide allergy
30
carbonic anhydrase inhibitor side effects
drops: -burning, blurred vision, blepharitis, taste disturbances oral: -ataxia, confusion, photosensitivity, nausea, metabolic acidosis
31
dorzolamide class and brand
CAI trusopt
32
dorzolamide + timolol class and brand
CAI Cosopt, Cosopt PF
33
brinzolamide class and brand
CAI Azopt
34
Acetazolamide class and brand
CAI (oral) no brand
35
Methazolamide
CAI (oral) no brand
36
Rho Kinase Inhibitor MOA
increase aqueous humor outflow
37
rho kinase dosing
1 drop QPM (reduce IOP by 25-30%)
38
rho kinase side effects
-burning -corneal disease -conjunctival hemorrhage -conjunctival hyperemia
39
Netarsudil class and brand
CAI Rhopressa
40
Netarsudil + Latanoprost class and brand
CAI Rocklatan
41
cholinergic MOA
increase aqueous humor outflow
42
cholinergic dosing
1-2 drops up to TID 1-2 drops up to QID
43
cholinergic CI and warnings
-use in caution in patients with history of retinal detachment or corneal abrasion
44
cholinergic side effects
-pupil constriction -corneal clouding -hypotension -bronchospasm -abdominal cramps
45
carbachol class and brand
cholinergics milostat
46
pilocarpine class and brand
cholinergic Isoptocarpine
47
what are the treatments of closed-angle glaucoma
Mannitol, glycerin, surgery
48
Mannitol
Hyperosmotic agents IV 1.5-2 g/kg/dose over 30 minutes
49
Glycerin
Hyperosmotic agent PO 1-2 g/kg/dose every hours as required
50
what are medications that increase IOP
-anticholinergics -chronic steroids -decongestants -topiramate -antidepressants