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therapeutics 2 > Antipsychotic Adverse Effects > Flashcards

Antipsychotic Adverse Effects Flashcards

1
Q

what are the 3 main types of AE categories of antipsychotics

A

autonomic
central nervous system
endocrine

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2
Q

what are the manifestations of autonomic AEs

A

loss of accommodation
dry mouth
difficulty urinating
constipation
orthostatic hypotension
impotence

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3
Q

what are the mechanisms of autonomic AEs

A

muscarinic cholinoceptor blockade
alpha adrenoceptor blockade

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4
Q

what are the manifestations of CNS AEs

A

parkinson’s syndrome
akathasia
dystonias
tardive dyskinesia
toxic-confusional state
sedation
weight gain

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5
Q

what are the mechanisms of CNS AEs

A

dopamine receptor blockade
supersensitivity of dopamine receptors
muscarinic blockade
H1 receptor blockade

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6
Q

what are the manifestations of endocrine AEs

A

amenorrhea-galactorrhea
infertility
impotence

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7
Q

what are the mechanisms of endocrine AEs

A

dopamine receptor blockade resulting in hyperprolactinemia

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8
Q

what is the main SE of chlorpromazine

A

1st antipsychotic
antihistamine side effects

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9
Q

what is the main SE of promethazine

A

antihistamine
antiemetic

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10
Q

what is the main SE of thioridazine

A

many SEs:
anticholinergic
sedation
sexual dysfunction
cardiovascular

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11
Q

what is the main SE of fluephenazine

A

EPS

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12
Q

what is the main SE of prochlorperazine

A

antiemetic

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13
Q

what is the main SE of perphenazine

A

CATIE studies: combination with anticholinergic

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14
Q

what is the main SE of thiothixene

A

modest EPS

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15
Q

what is the main SE of haloperidol

A

EPS

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16
Q

what is the main SE of molindone

A

moderate EPS

17
Q

what is pimozide used for

A

tourette’s disease
supress motor and vocal tics

18
Q

key points for clozapine

A

1st aypical antipsychotic
agranulocytosis
risk of diabetes
superior efficacy

19
Q

key points for olanzapine

A

weight gain
risk of diabetes

20
Q

key points for quetiapine

A

metabolite w/ antidepressants activity
hypotension
sedation

21
Q

key points for risperidone

A

5HT2a/D2 receptor antagonist

22
Q

key points for Ziprasidone

A

5HT2a/D2 and alpha 1 affinity
prolongs QT interval

23
Q

key points for Lurasidone

A

5HT2a/D2
reduced metabolic effects
rapid titration

24
Q

key points for Aripiprazole

A

high 5HT2a/D2 affinity
partial agonist activity

therapeutics 2 (24 decks)

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