Antipsychotic Adverse Effects Flashcards
what are the 3 main types of AE categories of antipsychotics
autonomic
central nervous system
endocrine
what are the manifestations of autonomic AEs
loss of accommodation
dry mouth
difficulty urinating
constipation
orthostatic hypotension
impotence
what are the mechanisms of autonomic AEs
muscarinic cholinoceptor blockade
alpha adrenoceptor blockade
what are the manifestations of CNS AEs
parkinson’s syndrome
akathasia
dystonias
tardive dyskinesia
toxic-confusional state
sedation
weight gain
what are the mechanisms of CNS AEs
dopamine receptor blockade
supersensitivity of dopamine receptors
muscarinic blockade
H1 receptor blockade
what are the manifestations of endocrine AEs
amenorrhea-galactorrhea
infertility
impotence
what are the mechanisms of endocrine AEs
dopamine receptor blockade resulting in hyperprolactinemia
what is the main SE of chlorpromazine
1st antipsychotic
antihistamine side effects
what is the main SE of promethazine
antihistamine
antiemetic
what is the main SE of thioridazine
many SEs:
anticholinergic
sedation
sexual dysfunction
cardiovascular
what is the main SE of fluephenazine
EPS
what is the main SE of prochlorperazine
antiemetic
what is the main SE of perphenazine
CATIE studies: combination with anticholinergic
what is the main SE of thiothixene
modest EPS
what is the main SE of haloperidol
EPS
what is the main SE of molindone
moderate EPS
what is pimozide used for
tourette’s disease
supress motor and vocal tics
key points for clozapine
1st aypical antipsychotic
agranulocytosis
risk of diabetes
superior efficacy
key points for olanzapine
weight gain
risk of diabetes
key points for quetiapine
metabolite w/ antidepressants activity
hypotension
sedation
key points for risperidone
5HT2a/D2 receptor antagonist
key points for Ziprasidone
5HT2a/D2 and alpha 1 affinity
prolongs QT interval
key points for Lurasidone
5HT2a/D2
reduced metabolic effects
rapid titration
key points for Aripiprazole
high 5HT2a/D2 affinity
partial agonist activity
