Pharmacotherapy of Anxiety Flashcards
buspirone MOA
5HT-1a receptor agonist
what is buspirone used for
generalized anxiety
what is the buspirone dose in anxiety and how long will it take to work
10-15mg TID
may take up to 3-4 weeks for initial efficacy
how long should benzos be used for
short-term use
how and why to taper benzos
taper over weeks to months
acute withdrawal can lead to seizures
what are benzos on beer’s criteria for
fall risk, confusion, aggression
what are SEs of benzos
sedation
paradox excitement
swallowing issues
memory issues
overall impairment
what is hydroxyzine used for
generalized anxiety disorder
prn for insomnia or anxiety
who should avoid hydroxyzine
elderly due to anticholinergic side effects
what are the side effects of hydroxyzine
sedation
anticholinergic SEs
QTc prolongation
fall risk
what is propranolol used for
performance anxiety
how does propranolol work
decreases physiological symptoms of acute anxiety
what should be considered before starting propranolol
asthma and CV conditions
when to use gabapentinoids and quetiapine in anxiety
if patient has anxiety as well as bipolar or neuropathic pain
what are the warnings with Kava
may cause hepatotoxicity or liver failure
St. John’s P450
strong 3A4 inhibitor
when to avoid passionflower and valerian
pregnancy
when to avoid chamomile
ragweed allergy
what is first line for all anxiety disorders
SSRIs and SNRIs
buspirone
when can atypicals be used in anxiety
not for anxiety but can help in resistant OCD
when to use herbal therapies in anxiety
last line
what is the classification of GAD
excessive anxiety/worry for at least 6 months
what is 1st line for GAD
SSRIs and SNRIs (w/ pain syndromes)
when to use benzos in GAD
bridge therapy w/ SSRI/SNRI
