Assessment of Pain/Non-opioid Flashcards
what questions should be asked to assess subjective pain
PQRSTU
(palliative/precipitating, quality, region, severity, time related, impact on U)
what objective information should you collect to assess pain
behavior changes
physiological changes
what are the goals of therapy with pain
correct underlying pain
minimize pain and symptoms
improve QOL
limit drug side effects
non-pharm therapy options
correct underlying cause
exercise
acupuncture
physical manipulation
heat or ice
massage
WHO step 1 treatment
non-opioid +/- adjuvant analgesic
WHO step 2 treatment
opioid for mild to moderate pain
+ non opioid
+/- adjuvant analgesic
WHO step 3 treatment
opioid for moderate to severe main
+ non opioid
+/- adjuvant analgesic
when to step up in treatment
pain is persisting or increasing
when to step down in treatment
pain is resolving or toxicity occurs
what are examples of adjuvant therapy
gabapentinoids
SNRIs
TCAs
muscle relaxants
antiepileptics
topical agents
what are the non-opioid pain options
APAP
NSAIDs
acetaminophen uses
analgesic and antipyretic
acetaminophen formulations
tablet
capsule
chewable
liquid/gel
IV
suppository
acetaminophen recommended dosing for adults
325-1000mg PO q4-6h prn
acetaminophen max dose adults
3-4 g/day
acetaminophen max dose liver disease
2 g/day
acetaminophen dosing peds
10-15 mg/kg PO Q4H prn
acetaminophen max dose peds
75 mg/kg/day or 3-4 g/day
acetaminophen side effects
hepatotoxicity (greater than 10g dose)
what is acetaminophen the gold standard for
osteoarthritic in geriatric patients due to fewer side effects
education points for acetaminophen
max daily doses
combo products
what are NSAIDs used for
analgesic, antipyretic, anti-inflammatory
NSAID side effects
GI bleeding (black box warning)
nephrotoxicity
fluid retention
increase CV events
NSAID education points
take with food
who should avoid NSAIDs
geriatric patients
patients with cardiac history
severe liver or kidney disease
aspirin formulations
chewable
tablet
EC tablet
capsule
ER capsule
suppository
aspirin adult dosing
325-1000mg PO q4-6h PRN
aspirin adult max dose
4g/day
aspirin peds dosing
AVOID (reye’s syndrome)
what is reye’s syndrome
rare serious condition that causes swelling in the brain and liver
Ibuprofen formulations
capsule
tablet (200mg)
chewable
suspension
IV solution
ibuprofen adult dosing
200-800mg PO q6-8h PRN
ibuprofen adult max dose
3200mg/day
ibuprofen peds dosing
5-10mg/kg PO q4-6h PRN
ibuprofen peds max dose
40mg/day or 2400mg whichever is less
how old do kids have to be to take ibuprofen
> 6 months
diclofenac formulations
capsule
tablet
IV solution
suppository
topical gel/solution
eye solution
patch
diclofenac adult dose
50mg PO q8h or 2-4g topically 4 times/day
clinical pearls of diclofenal
minimal side effects with gel
naproxen formulations
capsule
tablet
DR/ER tablet
suspension
naproxen adult dosing
220-500mg PO q6-12h
naproxen adult max dose
1000mg/day
ketorolac formulations
tablet
iv/im solution
nasal spray
eye solution
ketorolac adult dosing
15-30 IM/IV q6h prn or 10mg q6h prn
ketorolac peds dosing
0.5mg/kg/dose IM/IV q6h prn
max duration of ketorolac
5 days (increased risk of GI bleed when used longer)
celecoxib adult dosing
200mg PO BID
celecoxib clinical pearl
cox 2 selective – less GI toxicity
gabapentinoid uses
fibromyalgia
neuropathies
post-op pain
gabapentin dosing
100-300mg PO TID (max 3600mg/day)
pregabalin dosing
75mg PO BID (max 600mg/day)
gabapentinoid side effects
sedation, dizziness, peripheral edema
gabapentinoid clinical pearls
renally dose adjusted
titrate up dose
use in combo to decrease dose requirements
pregabalin is schedule V
SNRI uses
fibromyalgia
neuropathy
venlafaxine dosing
37.5-75mg PO daily (max 225mg/day)
duloxetine dosing
30mg PO daily x 1 week then increase to 60mg PO daily (max)
SNRI side effects
nausea
headache
HTN
sedation
weakenss
SNRI clinical pearls
start low and titrate slow
renally dose adjust venlafaxine and avoid duloxetine for CrCl < 30 mL/min
TCA uses
fibromyalgia
neuropathy
migraine prophylaxis
amitriptyline or nortriptyline dosing
10mg PO qhs (max 150mg/day)
TCA side effects
anti-cholinergic side effects
sedation
TCA clinical pearls
last line for neuropathy and fibromyalgia due to side effects
muscle relaxant side effects
sedation/drowsiness
dizziness
dry mouth
vision changes
muscle relaxant pearls
short term use (<3 weeks)
carisoprodol is schedule IV
carbamazepine clinical pearls
increased risk of hypersensitivity reactions in patients with HLA-B*1502
autoinduction of hepatic enzymes
lidocaine side effects
hypotension
arrythmia
lidocaine clinical pearls
tachyphylaxis with continued use
12 hour break between patches
local affect so apply to where pain is
capsacian uses
muscle/joint pain
neuropathic pain
capsaician side effects
skin irritation and pain
capsaician clinical pearls
do not get in eyes
wash hands after applying
non cox-2 selective NSAIDs in geriatric patients
avoid chronic use
avoid short term schedule use when used in combo
indomethacin and ketorolac in geriatric patients
avoid
skeletal muscle relaxants in geriatric patients
avoid
SNRIs, TCAs, Carbamazepine in geriatric patients
use with caution
opioids and benzos in geriatric patients
avoid