Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

therapeutics 2 > Anticoagulation > Flashcards

Anticoagulation Flashcards

1
Q

overall steps of bridging therapy

A

stop warfarin 5 days prior to surgery
give LMWH or UFH until surgery (last dose 24 hours prior)
resume warfarin 24 hours after
overlap warfarin and LMWH for at least 5 days and INR therapeutic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

what are the drugs for post-op prophylaxis

A

dabigatran (hip only)
rivaroxaban
apixaban

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

what are the drugs for non-valve Afib

A

dabigatran
rivaroxaban
apixaban
edoxaban

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

what are the drugs for DVT/PE treatment

A

dabigatran
rivaroxaban
apixaban
edoxaban

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

what are the drugs for secondary prevention of DVT/PE

A

rivaroxaban
apixaban

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

what are the drugs for VTE prophylaxis

A

rivaroxaban

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Dabigatran MOA, reversal agent, and considerations

A

direct thrombin inhibitor
reversal = idarucizumab
avoid w/ renal impairment

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Rivaroxaban MOA, reversal agent, and considerations

A

Direct Xa inhibitor
reversal = adexanet
decrease dose with renal impairment

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Apixaban MOA, reversal agent, and considerations

A

Direct Xa inhibitor
reversal = adexanet
decrease dose with renal impairment

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Edoxaban MOA, reversal agent, and considerations

A

Direct Xa inhibitor
no reversal agent
cannot use if CrCl > 95 (afib only)
increased risk of hematoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

what is the initial warfarin dosing

A

5mg PO daily
overlap with UFH/LMWH/Xa for at least 5 days and until INR is therapeutic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

what is the main INR goal

A

2.0-3.0

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

what is the INR goal for aortic valve replacement and mechanical heart valve (mitral/high risk)

A

2.5-3.5

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

INR less than 2.o

A

increase dose by 5-15%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

INR 3.1-3.5

A

decrease dose by 5-15%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

INR 3.5-4.O

A

hold 1 dose
decrease dose by 10-15%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

INR > 4

A

hold 0-2 doses
decrease dose by 10-15%

18
Q

what are the questions to ask a warfarin patient

A

Drugs?
Diseases?
Doses missed?
Diet?
Drinking?
Signs of bleeding/bruising?

19
Q

UHF dosing, administration, reversal agent, and AEs

A

weight based dosing
IV bolus or infusion (rapid)
reversal = protamine sulfate
AE: thrombocytopenia

20
Q

LMWH dosing, admin, reversal agent

A

fixed or weight based dosing
longer half life so can be SQ
reversal = protamine sulfate

21
Q

HAT definition

A

mild decrease of platelets (<100,000)
occurs 48-72 hours
do not need to d/c heparin

22
Q

HIT definition

A

Platelet drops >50% baseline or > 100,000)
stop all heparin/warfarin and give alternative anticoag therapy
evaluate for thrombosis

23
Q

INR 4.5-10 + no evidence of bleeding

A

avoid VIT k

24
Q

INR > 10 + no evidence of bleeding

A

PO vitamin K

25
major bleeding on warfarin
Prothrombin complex concentrate or fresh frozen plasma *pcc is preferred and is faster*
26
CHADSVASc conditions and points
congestive HF = 1 hypertension = 1 age (75+) = 2 diabetes = 1 Stroke/TIA = 2 vascular disease = 1 age (65-74) = 1 female = 1
27
what are the 3 phases of platelet activation
adhesion: intact cells secrete PGI2 to inhibit thrombogenesis secretion: degranulation (ADP, TXA2, 5-HT vasoconstrictors) factors are secreted to recruit other platelets aggregation: factor activation induced confirmation for binding to fibrinogen to form clot
28
MOA of ADP inhibitors
P2Y12 is coupled to Gi and inhibits adenylyl cyclase. these drugs block P2Y12 and block aggregation
29
ADP inhibitor drugs
clopidogrel prasugrel ticagrelor cangrelor
30
MOA of GP iib/iiia receptor inhibitors
stops fibrinogen cross-linking at GPiib/iiia site
31
GP iib/iiia inhibitor drugs
eptifibatide tirofiban abciximab
32
MOA of PDE-3 inhibitors
platelet aggregation inhibitor inhibition of adenosine uptake
33
PDE-3 inhibitor drugs
dipyridamole cilostazol
34
Heparin (UFH) MOA
binds to free antithrombin changes confirmation increases interaction of AT with target factors
35
Heparin side effects
iatrogenic hemorrhage HIT osteoporosis
36
LMWH drugs
enoxaparin daltaparin
37
LMWH MOA
binds to antithrombin smaller so only binds to Factor Xa
38
LMWH side effects
HIT osteoporosis CI w/ renal failure
39
warfarin MOA
inhibits synthesis of factors II, VII, IX, and X
40
direct thrombin inhibitor drugs
bind to active site of thrombin inhibit soluble and fibrin-bound thrombin
41
direct thrombin drugs
bivalirudin argatroban dabigatran
42
Factor Xa inhibitors drugs
Fondaparinux Edoxaban Rivaroxaban Apixaban

therapeutics 2 (24 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions