Diabetes Exam 2 Flashcards

Question 1

Q

Normal FBG

Answer

A

< 100mg/dL

Question 2

Q

Normal OGTT

Answer

A

< 140 mg/dL

Question 3

Q

Normal A1c

Question 4

Q

Normal Random Glucose

Answer

A

< 200 mg/dL

Question 5

Q

Diabetic FBG

Answer

A

greater or equal to 126

Question 6

Q

Diabetic A1c

Answer

A

greater or equal to 6.5%

Question 7

Q

Diabetic random glucose

Answer

A

greater or equal 200

Question 8

Q

Diabetic OGTT

Answer

A

greater or equal 200

Question 9

Q

IFG

Question 10

Q

IGT

Question 11

Q

pre diabetic A1c

Answer

A

5.7 - 6.4

Question 12

Q

sulfonylureas structures

Answer

A

O
||
HN-C-NH

Question 13

Q

glinides structures

Answer

A

phenylalanine

  C + a ring
   | HN-C-COOH

Question 14

Q

SGLT2 inhibitor structures

Answer

A

glucose molecules hooked to bulky hydrophobic group

Question 15

Q

biguanides structures

Answer

A

NH \N/
|| |
/\ /
H2N N NH
H

Question 16

Q

Thiazolidinediones

Answer

A

thiazole on the ends

Question 17

Q

resistin

Answer

A

-elevated in T2DM
-mRNA dec due to TZD
-dec insulin sensitivity

Question 18

Q

Adiponectin

Answer

A

-dec in T2DM
-mRNA inc cue to TZD
-inc insulin sensitivity

Question 19

Q

TNF-alpha

Answer

A

-inc in T2DM
-mRNA dec due to TZDs
-dec insulin sensitivity

Question 20

Q

NPH

Answer

A

-slow onset
-long duration
-protamine w/ bound insulin

Question 21

Q

Lispro insulin (humalog)

Answer

A

-rapid onset
-short action
-reverse position of proline & lysine
-forces insulin not to dimerize

Question 22

Q

Insulin Aspart (Novolog)

Answer

A

-rapid onset
-short action
-proline switched to aspartate

Question 23

Q

Insulin Glulisine

Answer

A

-rapid onset
-short action
-switch Asn 3 to Lys and Lys 29 to Glu

Question 24

Q

Insulin Glargine (lantus)

Answer

A

-slow onset
-once daily
-Asn to Gly
-2 arg residues

Question 25

Q

Insulin Detemir

Answer

A

-slow onset
-once daily
-FA added & binds to albumin

Question 26

Q

Insulin Degludec

Answer

A

-slow onset
-once daily
-FA added & binds to albumin

Question 27

Q

sulfonylurea MOA

Answer

A

act as ATP to bind to Katp channels to close it

Question 28

Q

sulfonylurea AEs

Answer

A

hypoglycemia, GI problems, CV events, weight gain, inc secondary failure

Question 29

Q

sulfonylurea DDI

Answer

A

alcohol, high dose salicylates, thiazides, epi

Question 30

Q

Glinides vs sulfonylureas

Answer

A

same MOA and DDIs and AEs however there is less risk of hypoglycemia

Question 31

Q

TZDs MOA

Answer

A

bind to PPARy that affects gene transcription of adipokines