Pharmacotherapeutics

Question 1

Absorption

Answer 1

Movement of drugs into the bloodstream after administration

Question 2

Distribution

Answer 2

Transportation of medications to sites of action by bodily fluids

Question 3

Metabolism (bio transformation)

Answer 3

Changes medications into active or inactive forms by enzyme action
Primary in liver

Question 4

First pass effect

Answer 4

Liver inactivating some medication on their first pass through the liver

Question 5

Excretion

Answer 5

Elimination from the body primary through kidneys

Question 6

When should you obtain trough levels?

Answer 6

immediately before the next medication dose

Question 7

Half life

Answer 7

The time for the medication in the body to drop by 50%

Question 8

Pharmacodynamics

Answer 8

the interactions between medications and target cells,body systems and organs to produce effect

Question 9

Agonist

Answer 9

Drugs that activate receptors and produce desired response

Question 10

Antagonist

Answer 10

Drugs that prevent receptor activation and block a response

Question 11

Sublingual

Answer 11

Under the tongue

Question 12

Bucal

Answer 12

Between cheek and gum

Directly enters bloodstream and bypass the liver

Question 13

Transdermal

Answer 13

Medication in a skin path for absorption through the skin

Question 14

Eye drops

Answer 14

Drop medication into conjunctival sac

Question 15

Ear drops

Answer 15

For adults: pull ear up and out

Children: down and back

Question 16

Z tract

Answer 16

For IM injections to prevent medication from leaving back into subcutaneous tissue

Question 17

Category

Answer 17

Therapeutic purpose of drug (most general)

Question 18

Class

Answer 18

Can be used for one or more purpose based on method of action

Question 19

Pharmacokinetic phases

Answer 19

Absorption
Distribution
Metabolism
Excretion

Question 20

Pharmacokinetic phase

Answer 20

The study of the movement of drugs into, within, and out of the body

Question 21

Enteric coated drugs

Answer 21

Resist sonaba hace gastric acid but disintegrate in Amal images tones (alkaline environment)

Question 22

Passive

Answer 22

Diffusion

Question 23

Active

Answer 23

Needs carrier (enzyme protein) to move across concentration gradient

Question 24

Pinocytosis

Answer 24

Engulfing the drug particles

Question 25

What type of drugs pass easily through GI membrane

Answer 25

Mostly like and protein

Question 26

How can water soluble drugs pass through membrane

Answer 26

Need a carrier

Question 27

Absorb fastest as what

Answer 27

Lipid soluble and non ionized

Question 28

Nonionized

Answer 28

Large particles pass through membrane

Question 29

Bioavailability

Answer 29

% administered drug dose available for activity
IV=100%
PO=<100%

Question 30

Steady state

Answer 30

Amount of drug being administered in the same as the amount eliminated

Question 31

Loading dose

Answer 31

Large initial dose

Question 32

Affinity

Answer 32

Amount of attraction between med and site

Question 33

Potency

Answer 33

Power of med to create a response

Question 34

Peak

Answer 34

Highest concentration of drug at specific time
Indicate the rate of absorption of drug
Blood sample should be drawn at peak time

Question 35

Trough

Answer 35

Lowest plasma concentration

Measures rage at which drug is eliminated

Question 36

Adverse reactions

Answer 36

More severe than side effects and are always unintentional