Antimicrobial Therapy Flashcards
Antimicrobial therapy
The use of medications to treat infections due to bacteria, viruses, or fungi
Narrow spectrum antibiotics
Only Few types of bacteria are sensitive
Broad spectrum antibiotic
Wide variety of bacteria
Bactericidal medication
Directly lethal to the microorganism
Sulfonomides
Can produce kernicterus, a severe neurologic disorder in newborns
Gentamicin
Causes hearing loss in infants
Tetracyclines
Cause discoloration of developing teeth
Empiric therapy
Prior to definitive diagnosis
Prophylactic therapy
Skin
Therapeutic therapy
Treated therapeutic
Amoxycillin pregnancy category
Category B
Amoxicillin drug lab food interactions
Increase effect with aspirin
Decrease effect with acidic juices
Amoxicillin side effects
Nausea, vomiting diarrhea Abdominal pain Rash Edema Dizziness Insomnia Anxiety Confusion
Adverse reactions of amoxicillin
Super infections
Blood dyscrasias
Bone marrow depression
Steven Johnson syndrome
Cephalosporins
Beta lactan structure and inhibit bacterial enzyme necessary for cell wall cell wall synthesis
Cephalosporins drug interactions
Don’t take with Alcohol= flushing dizziness, headache, don’t wake with nausea, vomiting, muscular cramps
First generation cephalosporins
Used for surgical prophylaxis
Destroyed by beta lactamases
Effective against gram + bacteria
Second generation cephalosporins
Same effectiveness as first generation but more active against some gram - organisms
First generation cephalosporins prototype
Cefazolin sodium (Ancef) IM and IV
Second generation cephalosoprin prototype
Cefaclor(Cecile) PO
Cefazolin and Cefaclor therapeutic uses
Respiro ry, urinary skin interaction and especially surgical prophylaxis
4th generation cephalosporins
Greater spectrum of antimicrobiano activity and greater stability against breakdown of beta lax games enzymes compared to 3rd generation
Cephalosporin use on adults and children
Children: used extensively for children
Older adults: decreased renal function
Sepsis
Potentially life threatening condition caused by the body’s response to and infection