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MSK > Pharmacology Review Q's > Flashcards

Pharmacology Review Q's Flashcards

1. Non-Steroidal Anti-inflammatory Drugs 1 (NSAIDs) (1-18)

1
Q

Which of the following only inhibits COX-2? a. Ibuprofen b. Paracetamol c. Celecoxib d. Diclofenec e. Piroxicam f. Misoprostol

A

c. Celecoxib

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2
Q

Which of the following reduces gastric acid secretion? a. Ibuprofen b. Naproxen c. Celecoxib d. Diclofenec e. Piroxicam f. Misoprostol

A

f. Misoprostol

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3
Q

Which of the following is derived from 5-lipoxygenase? a. Prostaglandins b. Leukotrienes c. Thromboxanes

A

b. Leukotrienes

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4
Q

Which of the following is known as a housekeeping prostaglandin? a. COX-1 B. COX-2

A

a. COX-1

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5
Q

Which of the following is NOT inhibited by aspirin? a. Prostaglandins b. Leukotrienes c. Thromboxanes d. they’re all inhibited

A

b. Leukotrienes

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6
Q

Which of the following is the predominant inflammatory prostanoid? a. PGD2 b. PGF2a c. PGI2 d. TXA2 e. PGE2

A

e. PGE2

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7
Q

Which of the following causes uterine contraction? a. PGD2 b. PGF2a c. PGI2 d. TXA2 e. PGE2

A

b. PGF2a

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8
Q

Which of the following causes relaxation of gastrointestinal smooth muscle? a. EP1R b. EP2R c. EP3R

A

b. EP2R

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9
Q

Which of the following causes contraction of gastrointestinal smooth muscle? a. EP1R b. EP2R c. EP3R d. EP4R

A

a. EP1R

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10
Q

Which of the following causes inhibition of gastric acid? a. EP1R b. EP2R c. EP3R d. EP4R

A

c. EP3R

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11
Q

Which of the following causes similar action of EP4R? a. EP1R b. EP2R c. EP3R

A

b. EP2R

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12
Q

Which of the following physiological symptoms occur last when asprin is consumed? a. antiplatelet b. antipyretic c. antiinflammatory d. analgesic

A

c. antiinflammatory

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13
Q

Which of the following doesn’t cause an anti inflammatory effect? a. Ibuprofen b. Paracetamol c. Celecoxib d. Diclofenec e. Piroxicam f. Misoprostol

A

b. Paracetamol

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14
Q

Which of the following best describes the theory that explains why COX-2 inhibitors cause cardiovascular events?

a. blocks PGI1 release, increases TX2
b. blocks PGI2 release, increases TX2
c. blocks PGD2 release, increases TX2
d. blocks PGD2 release, decreases TX2

A

b. blocks PGI2 release, increases TX2

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15
Q

Which of the following may occur when aspirin is consumed? a. respiratory acidosis b. respiratory alkalosis

A

b. respiratory alkalosis

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16
Q

Which TWO organs are most likely affected by long term use of aspirin? a. liver b. stomach c. spleen d. kidney

A

b. stomach & d. kidney

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17
Q

Which of the following cannot be given to gout patients? a. Ibuprofen b. Paracetamol c. Aspirin d. Diclofenec e. Piroxicam

A

c. Aspirin

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18
Q

A child comes in with an enlarged liver, headache, and neck stiffness. Parents said they gave him aspirin a day ago. Which diagnosis is more likely? a. Hypersensitivity b. Reye’s syndrome c. Respiratory depression

A

b. Reye’s syndrome (swelling in liver and brain)

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19
Q

Which TWO of the following commonly cause GI disturbances? a. Indomethacin b. Ibuprofen c. Paracetamol d. Aspirin e. Naproxen f. Piroxicam g. Celecoxib h. Diclofenec i. Misoprostol

A

a. Indomethacin & d. Aspirin

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20
Q

Which of the following causes increased heart attacks and strokes? a. Indomethacin b. Ibuprofen c. Paracetamol d. Aspirin e. Naproxen f. Piroxicam g. Celecoxib h. Diclofenec i. Misoprostol

A

g. Celecoxib

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21
Q

Which of the following has a long half-life, and thus can be used twice daily? a. Indomethacin b. Ibuprofen c. Paracetamol d. Aspirin e. Naproxen f. Piroxicam g. Celecoxib h. Diclofenec i. Misoprostol

A

f. Piroxicam

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22
Q

Which of the following is considered the safest NSAID? a. Indomethacin b. Ibuprofen c. Paracetamol d. Aspirin e. Naproxen f. Piroxicam g. Celecoxib h. Diclofenec i. Misoprostol

A

e. Naproxen

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23
Q

Which of the following very potent and may cause CNS disturbances? a. Indomethacin b. Ibuprofen c. Paracetamol d. Aspirin e. Naproxen f. Piroxicam g. Celecoxib h. Diclofenec i. Misoprostol

A

a. Indomethacin

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24
Q

Low oral absorbtion makes this drug beneficial for IBD a. Azathioprine b. Methotrexate c. Leflunomide d. Sulfasalazine

A

d. Sulfasalazine

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25
Q

Which Sulfasalazine derivative is theorized to limit some interleukins? a. sulfapyridine b. 5-amino salicylic acid

A

a. sulfapyridine

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26
Q

Which is a folic acid antagonist (and analogue)? a. Azathioprine b. Methotrexate c. Leflunomide d. Sulfasalazine

A

b. Methotrexate

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27
Q

Which purine nucleoside base suppresses inflammation?

A

adenosine (it builds up when Methotrexate is taken)

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28
Q

Which Sulfasalazine derivative clear ROS? a. sulfapyridine b. 5-amino salicylic acid

A

b. 5-amino salicylic acid

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29
Q

Which drug has a very long half life? a. Etanercept b. Methotrexate c. Leflunomide d. Sulfasalazine

A

c. Leflunomide

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30
Q

Which DMARDS is commonly the first choice? a. Azathioprine b. Methotrexate c. Tofacitinib d. Sulfasalazine

A

b. Methotrexate

31
Q

Which drug inhibits JAK? a. Anankira b. Methotrexate c. Tofacitinib d. Sulfasalazine

A

c. Tofacitinib

32
Q

Which drug stops denovo pyrimidine synthesis? a. Etanercept b. Methotrexate c. Leflunomide d. Sulfasalazine

A

c. Leflunomide

33
Q

Which DMARDS has a faster in onset? a. Azathioprine b. Methotrexate c. Tofacitinib d. Sulfasalazine

A

b. Methotrexate

34
Q

Which drug is an IL-1 antagonist? a. Anankira b. Methotrexate c. Tofacitinib d. Sulfasalazine

A

a. Anankira

35
Q

Which drug may lead to increased secondary malignancy? a. Anankira b. Methotrexate c. Tofacitinib d. Sulfasalazine

A

a. Tofacitinib

36
Q

Which is a purine analogue? a. Azathioprine b. D-penicillamine c. Tofacitinib d. Sulfasalazine

A

a. Azathioprine

37
Q

Which drug is only half absorbed? a. Anankira b. Tofacitinib c. D-penicillamine d. Azathioprine

A

c. D-penicillamine

38
Q

Which drug interacts with allopurinol? a. Azathioprine b. Methotrexate c. Leflunomide d. D-penicillamine

A

a. Azathioprine

39
Q

Which drug has a side effect of taste disturbance? a. Anankira b. Tofacitinib c. D-penicillamine d. Azathioprine

A

c. D-penicillamine

40
Q

Which TWO drugs are used to stop tissue rejection in transplants? a. Azathioprine b. Methotrexate c. Leflunomide d. Sulfasalazine

A

a. Azathioprine & c. Leflunomide (cyclosporin-A is also for graft rejection)

41
Q

Which drug is passed onto breast milk? a. Chloroquine b. Tofacitinib c. Anakinra d. Azathioprine

A

a. Chloroquine

42
Q

Which drug can be used to treat Willson’s disease? a. Chloroquine b. Cyclosporin-A c. D-penicillamine d. Etanercept

A

c. D-penicillamine

43
Q

Which drug is an antibody against the protein CD20, which is found on immune cell B cells? a. Infliximab b. Etanercept c. Rituximab d. Anakinra

A

c. Rituximab

44
Q

Which drug has been reported to cause demyelinating CNS disorders?

a. Chloroquine
b. Etanercept
c. Infliximab
d. Anakinra

A

b. Etanercept

45
Q

Which drug should not be given to a patient with G6PD? a. Chloroquine b. Tofacitinib c. D-penicillamine d. Azathioprine

A

a. Chloroquine

46
Q

Which of the following does NOT cause BM suppression?

a. Azathioprine
b. Methotrexate
c. Cyclosporin-A
d. D-penicillamine

A

c. Cyclosporin-A

47
Q

Which drug inhibits thymidylate synthesis? a. Azathioprine b. Methotrexate c. Cyclosporin-A d. D-penicillamine

A

b. Methotrexate

48
Q

Which drug Inhibits dihydroorotate dehydrogenase? a. Azathioprine b. Methotrexate c. Leflunomide d. D-penicillamine

A

c. Leflunomide

49
Q

Which is found in fungus? a. Azathioprine b. Methotrexate c. Cyclosporin-A d. D-penicillamine

A

c. Cyclosporin-A

50
Q

Which drug works by inhibiting IL-1 synthesis? a. Chloroquine b. Tofacitinib c. D-penicillamine d. Rituximab

A

c. D-penicillamine

51
Q

Which drug has side effects of ocular toxicity? a. Chloroquine b. Tofacitinib c. Anakinra d. Azathioprine

A

a. Chloroquine

52
Q

Which drug has a long (plasma) half-life? a. Rituximab b. Methotrexate c. Leflunomide d. D-penicillamine

A

c. Leflunomide

53
Q

Which drug blocks IACAR transformylase? a. Methotrexate b. Tofacitinib c. D-penicillamine d. Azathioprine

A

a. Methotrexate

54
Q

Which of the following inhibits IL-2 synthesis? a. Azathioprine b. Methotrexate c. Cyclosporin-A d. Leflunomide

A

c. Cyclosporin-A

55
Q

Which of the following works against TNF-alpha? a. Infliximab b. Etanercept c. Rituximab d. Cyclosporin-A

A

a. Infliximab

56
Q

Which drug has been reported to cause a latent TB activation? a. Chloroquine b. Etanercept c. Infliximab d. Anakinra

A

c. Infliximab

57
Q

Which drug is only used for severe RA, where other drugs failed? a. Chloroquine b. Etanercept c. Infliximab d. Anakinra

A

d. Anakinra

58
Q

Which drug acts as a TNF-alpha receptor? a. Infliximab b. Etanercept c. Rituximab d. Anakinra

A

b. Etanercept

59
Q

What two drugs affect IL-1?

A

Anankira (its antagonist) D-penicillamine (stops its synthesis)

60
Q

What drugs have been developed for RA patients that decrease mortality?

A

disease-modifying anti-rheumatic drugs (DMARDS)

61
Q

Which NSAID is often used for gout treatment?

  1. prednisone
  2. aspirin
  3. colchicine
  4. indomethacin
A

c. indomethacin

62
Q

Which is used for patients who cannot have NSAIDs?

  1. naproxen
  2. aspirin
  3. febuxostat
  4. indomethacin
  5. prednisone
A

e. prednisone

63
Q

Which of the following makes gout worse?

  1. naproxen
  2. aspirin
  3. febuxostat
  4. indomethacin
  5. prednisone
A

b. aspirin

64
Q

Why shouldn’t we give aspirin to gout patients?

A

it inhibits uric acid secretion

65
Q

Which of the following has side effects of nausea, vomiting, and diarrhea?

  1. allopurinol
  2. febuxostat
  3. colchicine
  4. indomethacin
  5. prednisone
A

c. colchicine

66
Q

Which of the following are Xanthine oxidase inhibitors?

  1. allopurinol
  2. febuxostat
  3. colchicine
  4. indomethacin
  5. prednisone
A

a. allopurinol & b. febuxostat

67
Q

Which of the following is safer to use in patients with kidney transplants?

  1. allopurinol
  2. febuxostat
A

b. febuxostat (metabolized in the liver)

68
Q

Which of the following inhibit uric acid reabsorption?

  1. indomethacin
  2. probenecid
  3. febuxostat
  4. pegloticase
A

b. probenecid

69
Q

Which of the following uric acid reabsorption inhibitors causes urinary stones or uric acid deposition?

  1. losartan
  2. probenecid
A

b. probenecid (A isn’t on the drug list. uricosuric drugs excrete uric acid so it can build up and cause stone formation)

70
Q

Which of the following disrupts granulocyte migration to the joint?

  1. allopurinol
  2. febuxostat
  3. colchicine
  4. indomethacin
  5. prednisone
A

c. colchicine (by binding to tubulin and becoming a mitotic prison)

71
Q

Which of the following is an analog of hypoxanthine?

  1. allopurinol
  2. febuxostat
A

a. allopurinol

72
Q

Which of the following can have side effects of gastrointestinal disturbances?

  1. allopurinol
  2. febuxostat
A

a. allopurinol

73
Q

Which of the following is a non-purine inhibitor of XO?

  1. allopurinol
  2. febuxostat
A

b. febuxostat

74
Q

What is the function of urate oxidase? and why is it important?

A

its an enzyme that converts uric acid to allantoin. its important because allantoin is much more excretable in the urine.

MSK (16 decks)

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