Pharmacology Review Q's

Question 1

Which of the following only inhibits COX-2? a. Ibuprofen b. Paracetamol c. Celecoxib d. Diclofenec e. Piroxicam f. Misoprostol

Answer 1

c. Celecoxib

Question 2

Which of the following reduces gastric acid secretion? a. Ibuprofen b. Naproxen c. Celecoxib d. Diclofenec e. Piroxicam f. Misoprostol

Answer 2

f. Misoprostol

Question 3

Which of the following is derived from 5-lipoxygenase? a. Prostaglandins b. Leukotrienes c. Thromboxanes

Answer 3

b. Leukotrienes

Question 4

Which of the following is known as a housekeeping prostaglandin? a. COX-1 B. COX-2

Answer 4

a. COX-1

Question 5

Which of the following is NOT inhibited by aspirin? a. Prostaglandins b. Leukotrienes c. Thromboxanes d. they’re all inhibited

Answer 5

b. Leukotrienes

Question 6

Which of the following is the predominant inflammatory prostanoid? a. PGD2 b. PGF2a c. PGI2 d. TXA2 e. PGE2

Answer 6

e. PGE2

Question 7

Which of the following causes uterine contraction? a. PGD2 b. PGF2a c. PGI2 d. TXA2 e. PGE2

Answer 7

b. PGF2a

Question 8

Which of the following causes relaxation of gastrointestinal smooth muscle? a. EP1R b. EP2R c. EP3R

Answer 8

b. EP2R

Question 9

Which of the following causes contraction of gastrointestinal smooth muscle? a. EP1R b. EP2R c. EP3R d. EP4R

Answer 9

a. EP1R

Question 10

Which of the following causes inhibition of gastric acid? a. EP1R b. EP2R c. EP3R d. EP4R

Answer 10

c. EP3R

Question 11

Which of the following causes similar action of EP4R? a. EP1R b. EP2R c. EP3R

Answer 11

b. EP2R

Question 12

Which of the following physiological symptoms occur last when asprin is consumed? a. antiplatelet b. antipyretic c. antiinflammatory d. analgesic

Answer 12

c. antiinflammatory

Question 13

Which of the following doesn’t cause an anti inflammatory effect? a. Ibuprofen b. Paracetamol c. Celecoxib d. Diclofenec e. Piroxicam f. Misoprostol

Answer 13

b. Paracetamol

Question 14

Which of the following best describes the theory that explains why COX-2 inhibitors cause cardiovascular events?

a. blocks PGI1 release, increases TX2
b. blocks PGI2 release, increases TX2
c. blocks PGD2 release, increases TX2
d. blocks PGD2 release, decreases TX2

Answer 14

b. blocks PGI2 release, increases TX2

Question 15

Which of the following may occur when aspirin is consumed? a. respiratory acidosis b. respiratory alkalosis

Answer 15

b. respiratory alkalosis

Question 16

Which TWO organs are most likely affected by long term use of aspirin? a. liver b. stomach c. spleen d. kidney

Answer 16

b. stomach & d. kidney

Question 17

Which of the following cannot be given to gout patients? a. Ibuprofen b. Paracetamol c. Aspirin d. Diclofenec e. Piroxicam

Answer 17

c. Aspirin

Question 18

A child comes in with an enlarged liver, headache, and neck stiffness. Parents said they gave him aspirin a day ago. Which diagnosis is more likely? a. Hypersensitivity b. Reye’s syndrome c. Respiratory depression

Answer 18

b. Reye’s syndrome (swelling in liver and brain)

Question 19

Which TWO of the following commonly cause GI disturbances? a. Indomethacin b. Ibuprofen c. Paracetamol d. Aspirin e. Naproxen f. Piroxicam g. Celecoxib h. Diclofenec i. Misoprostol

Answer 19

a. Indomethacin & d. Aspirin

Question 20

Which of the following causes increased heart attacks and strokes? a. Indomethacin b. Ibuprofen c. Paracetamol d. Aspirin e. Naproxen f. Piroxicam g. Celecoxib h. Diclofenec i. Misoprostol

Answer 20

g. Celecoxib

Question 21

Which of the following has a long half-life, and thus can be used twice daily? a. Indomethacin b. Ibuprofen c. Paracetamol d. Aspirin e. Naproxen f. Piroxicam g. Celecoxib h. Diclofenec i. Misoprostol

Answer 21

f. Piroxicam

Question 22

Which of the following is considered the safest NSAID? a. Indomethacin b. Ibuprofen c. Paracetamol d. Aspirin e. Naproxen f. Piroxicam g. Celecoxib h. Diclofenec i. Misoprostol

Answer 22

e. Naproxen

Question 23

Which of the following very potent and may cause CNS disturbances? a. Indomethacin b. Ibuprofen c. Paracetamol d. Aspirin e. Naproxen f. Piroxicam g. Celecoxib h. Diclofenec i. Misoprostol

Answer 23

a. Indomethacin

Question 24

Low oral absorbtion makes this drug beneficial for IBD a. Azathioprine b. Methotrexate c. Leflunomide d. Sulfasalazine

Answer 24

d. Sulfasalazine

Question 25

Which Sulfasalazine derivative is theorized to limit some interleukins? a. sulfapyridine b. 5-amino salicylic acid

Answer 25

a. sulfapyridine

Question 26

Which is a folic acid antagonist (and analogue)? a. Azathioprine b. Methotrexate c. Leflunomide d. Sulfasalazine

Answer 26

b. Methotrexate

Question 27

Which purine nucleoside base suppresses inflammation?

Answer 27

adenosine (it builds up when Methotrexate is taken)

Question 28

Which Sulfasalazine derivative clear ROS? a. sulfapyridine b. 5-amino salicylic acid

Answer 28

b. 5-amino salicylic acid

Question 29

Which drug has a very long half life? a. Etanercept b. Methotrexate c. Leflunomide d. Sulfasalazine

Answer 29

c. Leflunomide

Question 30

Which DMARDS is commonly the first choice? a. Azathioprine b. Methotrexate c. Tofacitinib d. Sulfasalazine

Answer 30

b. Methotrexate

Question 31

Which drug inhibits JAK? a. Anankira b. Methotrexate c. Tofacitinib d. Sulfasalazine

Answer 31

c. Tofacitinib

Question 32

Which drug stops denovo pyrimidine synthesis? a. Etanercept b. Methotrexate c. Leflunomide d. Sulfasalazine

Answer 32

c. Leflunomide

Question 33

Which DMARDS has a faster in onset? a. Azathioprine b. Methotrexate c. Tofacitinib d. Sulfasalazine

Answer 33

b. Methotrexate

Question 34

Which drug is an IL-1 antagonist? a. Anankira b. Methotrexate c. Tofacitinib d. Sulfasalazine

Answer 34

a. Anankira

Question 35

Which drug may lead to increased secondary malignancy? a. Anankira b. Methotrexate c. Tofacitinib d. Sulfasalazine

Answer 35

a. Tofacitinib

Question 36

Which is a purine analogue? a. Azathioprine b. D-penicillamine c. Tofacitinib d. Sulfasalazine

Answer 36

a. Azathioprine

Question 37

Which drug is only half absorbed? a. Anankira b. Tofacitinib c. D-penicillamine d. Azathioprine

Answer 37

c. D-penicillamine

Question 38

Which drug interacts with allopurinol? a. Azathioprine b. Methotrexate c. Leflunomide d. D-penicillamine

Answer 38

a. Azathioprine

Question 39

Which drug has a side effect of taste disturbance? a. Anankira b. Tofacitinib c. D-penicillamine d. Azathioprine

Answer 39

c. D-penicillamine

Question 40

Which TWO drugs are used to stop tissue rejection in transplants? a. Azathioprine b. Methotrexate c. Leflunomide d. Sulfasalazine

Answer 40

a. Azathioprine & c. Leflunomide (cyclosporin-A is also for graft rejection)

Question 41

Which drug is passed onto breast milk? a. Chloroquine b. Tofacitinib c. Anakinra d. Azathioprine

Answer 41

a. Chloroquine

Question 42

Which drug can be used to treat Willson's disease? a. Chloroquine b. Cyclosporin-A c. D-penicillamine d. Etanercept

Answer 42

c. D-penicillamine

Question 43

Which drug is an antibody against the protein CD20, which is found on immune cell B cells? a. Infliximab b. Etanercept c. Rituximab d. Anakinra

Answer 43

c. Rituximab

Question 44

Which drug has been reported to cause demyelinating CNS disorders? a. Chloroquine b. Etanercept c. Infliximab d. Anakinra

Answer 44

b. Etanercept

Question 45

Which drug should not be given to a patient with G6PD? a. Chloroquine b. Tofacitinib c. D-penicillamine d. Azathioprine

Answer 45

a. Chloroquine

Question 46

Which of the following does NOT cause BM suppression? a. Azathioprine b. Methotrexate c. Cyclosporin-A d. D-penicillamine

Answer 46

c. Cyclosporin-A

Question 47

Which drug inhibits thymidylate synthesis? a. Azathioprine b. Methotrexate c. Cyclosporin-A d. D-penicillamine

Answer 47

b. Methotrexate

Question 48

Which drug Inhibits dihydroorotate dehydrogenase? a. Azathioprine b. Methotrexate c. Leflunomide d. D-penicillamine

Answer 48

c. Leflunomide

Question 49

Which is found in fungus? a. Azathioprine b. Methotrexate c. Cyclosporin-A d. D-penicillamine

Answer 49

c. Cyclosporin-A

Question 50

Which drug works by inhibiting IL-1 synthesis? a. Chloroquine b. Tofacitinib c. D-penicillamine d. Rituximab

Answer 50

c. D-penicillamine

Question 51

Which drug has side effects of ocular toxicity? a. Chloroquine b. Tofacitinib c. Anakinra d. Azathioprine

Answer 51

a. Chloroquine

Question 52

Which drug has a long (plasma) half-life? a. Rituximab b. Methotrexate c. Leflunomide d. D-penicillamine

Answer 52

c. Leflunomide

Question 53

Which drug blocks IACAR transformylase? a. Methotrexate b. Tofacitinib c. D-penicillamine d. Azathioprine

Answer 53

a. Methotrexate

Question 54

Which of the following inhibits IL-2 synthesis? a. Azathioprine b. Methotrexate c. Cyclosporin-A d. Leflunomide

Answer 54

c. Cyclosporin-A

Question 55

Which of the following works against TNF-alpha? a. Infliximab b. Etanercept c. Rituximab d. Cyclosporin-A

Answer 55

a. Infliximab

Question 56

Which drug has been reported to cause a latent TB activation? a. Chloroquine b. Etanercept c. Infliximab d. Anakinra

Answer 56

c. Infliximab

Question 57

Which drug is only used for severe RA, where other drugs failed? a. Chloroquine b. Etanercept c. Infliximab d. Anakinra

Answer 57

d. Anakinra

Question 58

Which drug acts as a TNF-alpha receptor? a. Infliximab b. Etanercept c. Rituximab d. Anakinra

Answer 58

b. Etanercept

Question 59

What two drugs affect IL-1?

Answer 59

Anankira (its antagonist) D-penicillamine (stops its synthesis)

Question 60

What drugs have been developed for RA patients that decrease mortality?

Answer 60

disease-modifying anti-rheumatic drugs (DMARDS)

Question 61

Which NSAID is often used for gout treatment? 1. prednisone 2. aspirin 3. colchicine 4. indomethacin

Answer 61

c. indomethacin

Question 62

Which is used for patients who cannot have NSAIDs? 1. naproxen 2. aspirin 3. febuxostat 4. indomethacin 5. prednisone

Answer 62

e. prednisone

Question 63

Which of the following makes gout worse? 1. naproxen 2. aspirin 3. febuxostat 4. indomethacin 5. prednisone

Answer 63

b. aspirin

Question 64

Why shouldn't we give aspirin to gout patients?

Answer 64

it inhibits uric acid secretion

Question 65

Which of the following has side effects of nausea, vomiting, and diarrhea? 1. allopurinol 2. febuxostat 3. colchicine 4. indomethacin 5. prednisone

Answer 65

c. colchicine

Question 66

Which of the following are Xanthine oxidase inhibitors? 1. allopurinol 2. febuxostat 3. colchicine 4. indomethacin 5. prednisone

Answer 66

a. allopurinol & b. febuxostat

Question 67

Which of the following is safer to use in patients with kidney transplants? 1. allopurinol 2. febuxostat

Answer 67

b. febuxostat (metabolized in the liver)

Question 68

Which of the following inhibit uric acid reabsorption? 1. indomethacin 2. probenecid 3. febuxostat 4. pegloticase

Answer 68

b. probenecid

Question 69

Which of the following uric acid reabsorption inhibitors causes urinary stones or uric acid deposition? 1. losartan 2. probenecid

Answer 69

b. probenecid (A isn't on the drug list. uricosuric drugs excrete uric acid so it can build up and cause stone formation)

Question 70

Which of the following disrupts granulocyte migration to the joint? 1. allopurinol 2. febuxostat 3. colchicine 4. indomethacin 5. prednisone

Answer 70

c. colchicine (by binding to tubulin and becoming a mitotic prison)

Question 71

Which of the following is an analog of hypoxanthine? 1. allopurinol 2. febuxostat

Answer 71

a. allopurinol

Question 72

Which of the following can have side effects of gastrointestinal disturbances? 1. allopurinol 2. febuxostat

Answer 72

a. allopurinol

Question 73

Which of the following is a non-purine inhibitor of XO? 1. allopurinol 2. febuxostat

Answer 73

b. febuxostat

Question 74

What is the function of urate oxidase? and why is it important?

Answer 74

its an enzyme that converts uric acid to allantoin. its important because allantoin is much more excretable in the urine.