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Neurology > Pharmacology of Gout > Flashcards

Pharmacology of Gout Flashcards

1
Q

Which drugs treat acute symptoms of gout?

A
  1. Colchicine
  2. NSAIDs
  3. Prednisone
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2
Q

What is the MOA of colchicine?

A

Binds to tubulin to prevent its polymerization into microtubules; Leukocyte migration and phagocytosis are inhibited.

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3
Q

Side effects of Colchicine

A

Diarrhea, nausea

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4
Q

Side effects of prednisone

A

fluid retention

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5
Q

What is the most frequent side effect of Xanathine Oxidase inhibitors?

A

Rash; Allopurinol and Febuxostat

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6
Q

What is the MOA of Probenecid?

A

Inhibits the reabsorption of uric acid via URAT 1

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Neurology (30 decks)

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