Opioid Pharmacology Part 3

Question 1

Discuss Meperidine

Answer 1

1. 1/10th potency of morphine
2. Short duration 2-4 hrs
3. Mydriasis at toxic doses

Question 2

Discuss Methadone

Answer 2

1. Slow onset and long duration
2. Tolerance develops slowly
3. Less sedative

Question 3

Discuss Oxycodone

Answer 3

Used in combination with acetaminophen or aspirin

Question 4

Discuss Fentanyl

Answer 4

1. 100 times more potent than morphine

Question 5

Discuss Dextromethorphan

Answer 5

1. OTC antitussive

2. NDMA recepter antagonists at high doses

Question 6

Discuss Tramadol

Answer 6

1. Synthetic codeine analog

2. Inihibits uptake of NE and Serotonin

Question 7

Discuss Nalbuphine

Answer 7

Antagonist at mu, agonist at kappa

Question 8

Discuss Butorphanol

Answer 8

Partial agonist at mu, agonist at kappa

Question 9

Discuss Buprenorphrine

Answer 9

1. Partial mu agonist

2. Helps with withdrawal in low doses.

Question 10

What are the opioid receptor antagonists?

Answer 10

Naloxone and Naltrexone

Question 11

Discuss Naloxone

Answer 11

1. Blocks agonist effects of morphine.

2. DOA is 2 hrs

Question 12

Discuss Naltrexone

Answer 12

Longer DOA than Naloxone. Used to prevent relapse in chronic alcoholics

Question 13

Discuss opioid interactions with sedatives

Answer 13

Increased respiratory depression.

Question 14

Discuss opioid interactions with phenothiazines

Answer 14

Increased sedation and atropine like effects; A1 adrenergic antagonist effects.

Question 15

Discuss opioid interactions with MAO inhibitors

Answer 15

Hyperpyrexia, coma