Pharmacology of Drugs Used for Lung Cancer Flashcards
This type of lung cancer responds best to traditional cancer drugs as it is fast-growing.
Small cell lung cancer
What ADRs are associated with the lung cancer drug that inhibits the thymidylate kinase and dihydrofolate reductase?
Pemetrexed - low WBC, anemia
What is the MOA of Pembrolizumab?
Binds to PD-1 receptor on T cells to destory cancer cells
This cancer drugs acts by cross-linking DNA.
Cisplatin
What cancer drugs are bone marrow sparing?
Cisplatin, bleomycin, vincristine
Impaired wound healing is an ADR of this cancer drug.
Bevacizumab
What is the MOA of pemetrexed?
Inhibits folate-dependent processes by inhibiting the thymidylate kinase and dihydrofolate reductase
What is the MOA of gemcitabine?
DNA chain terminator
What ADRs are associated with Paclitaxel?
Peripheral neuropathy, infusion reactions
This cancer drug inhibits microtubule dissociation, blocking cell division in metaphase.
Paclitaxel
What ADRs are associated with cisplatin?
Nephrotoxicity, ototoxicity
This cancer drug is used in cancers that are EGFR positive.
Osimertibin - irreversible inhibitor of EGFR tyrosine kinase
What is the MOA of Bevacizumab?
Inhibits VEGF binding to prevent angiogenesis
What therapies must be co-administered with pemetrexed?
Folic acid & B12