Pharmacology of Drugs Used for Lung Cancer Flashcards

1
Q

This type of lung cancer responds best to traditional cancer drugs as it is fast-growing.

A

Small cell lung cancer

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2
Q

What ADRs are associated with the lung cancer drug that inhibits the thymidylate kinase and dihydrofolate reductase?

A

Pemetrexed - low WBC, anemia

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3
Q

What is the MOA of Pembrolizumab?

A

Binds to PD-1 receptor on T cells to destory cancer cells

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4
Q

This cancer drugs acts by cross-linking DNA.

A

Cisplatin

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5
Q

What cancer drugs are bone marrow sparing?

A

Cisplatin, bleomycin, vincristine

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6
Q

Impaired wound healing is an ADR of this cancer drug.

A

Bevacizumab

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7
Q

What is the MOA of pemetrexed?

A

Inhibits folate-dependent processes by inhibiting the thymidylate kinase and dihydrofolate reductase

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8
Q

What is the MOA of gemcitabine?

A

DNA chain terminator

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9
Q

What ADRs are associated with Paclitaxel?

A

Peripheral neuropathy, infusion reactions

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10
Q

This cancer drug inhibits microtubule dissociation, blocking cell division in metaphase.

A

Paclitaxel

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11
Q

What ADRs are associated with cisplatin?

A

Nephrotoxicity, ototoxicity

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12
Q

This cancer drug is used in cancers that are EGFR positive.

A

Osimertibin - irreversible inhibitor of EGFR tyrosine kinase

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13
Q

What is the MOA of Bevacizumab?

A

Inhibits VEGF binding to prevent angiogenesis

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14
Q

What therapies must be co-administered with pemetrexed?

A

Folic acid & B12

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