Pathology of Lung Cancers Flashcards
What is the histologic description of small cell carcinoma?
Small cells with scant cytoplasm, salt and pepper pattern
Small cell carcinoma is positive for what IHC stains?
Synaptophysin+, chromogranin A+, NSE +, CD56+, Ki67/MIB1+
This lung tumor is often an incidental finding discovered as coin lesions on routine CXR.
Pulmonary harmatoma
Central cavitation is most associated with what type of lung cancer?
Squamous cell carcinoma
This type of lung cancer is highly associated with cigarette smoking.
Small cell carcinoma
What gene mutations are associated with adenocarcinoma of the lung?
EGFR & KRAS
What histology findings are associated with squamous cell carcinoma of the lungs?
Keratin pearls, intercellular bridges
What is Trousseau syndrome?
Recurrent and migratory venous thromboses due to a hypercoagulable state in patients recently diagnosed with lung cancer
This type of non-small cell cancer lacks squamous and glandular differentiation.
Large cell carcinoma
These tumors grows as a polyploid mass and are confined to the mainstem bronchi.
Carcinoid tumors
What histologic finding is characteristic of adenocarcinoma of the lung?
Columnar cells with cytoplasmic mucin
This gene mutation is most associated with squamous cell lung carcinoma.
p53
Where is squamous cell carcinoma of the lung most commonly found?
Centrally, proximal to the bronchi; most common in the hilar region
Carcinoid syndrome is associated with excess release of what neurotransmitter?
Serotonin
Squamous cell carcinoma is positive for what IHC stains?
P63+, P40+, CK5/6+
What are the most common sites of metastatic tumors to the lung?
Breast, stomach, pancreas, colon
Where do solitary fibrous tumors arise in the lung?
In the pleura
What gene mutations are associated with small cell carcinoma of the lungs?
p53 and Rb inactivation, MYC amplification
Where is small cell carcinoma most commonly found in the lungs?
Centrally, near the hilar lymph nodes
Hypercalcemia is a paraneoplastic syndrome associated with what type of lung cancer?
Squamous cell lung carcinoma
Where is adenocarcinoma most commonly found in the lungs?
Periphery
This lung tumor is STAT-6+ and has a “patternless pattern.”
Solitary fibrous tumor
A patient is diagnosed with lung cancer. IHC testing confirms the cancer is TTF1+, NapsinA+, and mucicarmine +. What is the diagnosis?
Adenocarcinoma
This type of lung cancer is most common in women and non-smokers.
Adenocarcinoma
What is Pancoast syndrome?
A malignant neoplasm of the superior sulcus of the lung that causes shoulder pain and Horner syndrome
What paraneoplastic syndromes are associated with small cell lung cancer?
Cushing syndrome, SIADH
