Pathology of Lung Cancers

Question 1

What is the histologic description of small cell carcinoma?

Answer 1

Small cells with scant cytoplasm, salt and pepper pattern

Question 2

Small cell carcinoma is positive for what IHC stains?

Answer 2

Synaptophysin+, chromogranin A+, NSE +, CD56+, Ki67/MIB1+

Question 3

This lung tumor is often an incidental finding discovered as coin lesions on routine CXR.

Answer 3

Pulmonary harmatoma

Question 4

Central cavitation is most associated with what type of lung cancer?

Answer 4

Squamous cell carcinoma

Question 5

This type of lung cancer is highly associated with cigarette smoking.

Answer 5

Small cell carcinoma

Question 6

What gene mutations are associated with adenocarcinoma of the lung?

Answer 6

EGFR & KRAS

Question 7

What histology findings are associated with squamous cell carcinoma of the lungs?

Answer 7

Keratin pearls, intercellular bridges

Question 8

What is Trousseau syndrome?

Answer 8

Recurrent and migratory venous thromboses due to a hypercoagulable state in patients recently diagnosed with lung cancer

Question 9

This type of non-small cell cancer lacks squamous and glandular differentiation.

Answer 9

Large cell carcinoma

Question 10

These tumors grows as a polyploid mass and are confined to the mainstem bronchi.

Answer 10

Carcinoid tumors

Question 11

What histologic finding is characteristic of adenocarcinoma of the lung?

Answer 11

Columnar cells with cytoplasmic mucin

Question 12

This gene mutation is most associated with squamous cell lung carcinoma.

Answer 12

p53

Question 13

Where is squamous cell carcinoma of the lung most commonly found?

Answer 13

Centrally, proximal to the bronchi; most common in the hilar region

Question 14

Carcinoid syndrome is associated with excess release of what neurotransmitter?

Answer 14

Serotonin

Question 15

Squamous cell carcinoma is positive for what IHC stains?

Answer 15

P63+, P40+, CK5/6+

Question 16

What are the most common sites of metastatic tumors to the lung?

Answer 16

Breast, stomach, pancreas, colon

Question 17

Where do solitary fibrous tumors arise in the lung?

Answer 17

In the pleura

Question 18

What gene mutations are associated with small cell carcinoma of the lungs?

Answer 18

p53 and Rb inactivation, MYC amplification

Question 19

Where is small cell carcinoma most commonly found in the lungs?

Answer 19

Centrally, near the hilar lymph nodes

Question 20

Hypercalcemia is a paraneoplastic syndrome associated with what type of lung cancer?

Answer 20

Squamous cell lung carcinoma

Question 21

Where is adenocarcinoma most commonly found in the lungs?

Answer 21

Periphery

Question 22

This lung tumor is STAT-6+ and has a “patternless pattern.”

Answer 22

Solitary fibrous tumor

Question 23

A patient is diagnosed with lung cancer. IHC testing confirms the cancer is TTF1+, NapsinA+, and mucicarmine +. What is the diagnosis?

Answer 23

Adenocarcinoma

Question 24

This type of lung cancer is most common in women and non-smokers.

Answer 24

Adenocarcinoma

Question 25

What is Pancoast syndrome?

Answer 25

A malignant neoplasm of the superior sulcus of the lung that causes shoulder pain and Horner syndrome

Question 26

What paraneoplastic syndromes are associated with small cell lung cancer?

Answer 26

Cushing syndrome, SIADH