Pathology of Occupational Lung Disease Flashcards

1
Q

This type of asbestos is more pathogenic and associated with mesothelioma, but is less common.

A

Amphibole type

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

True/False. Rounded atelectasis is a life-threatening complication of asbestos exposure.

A

False - they are clinically benign plaques surrounding atelectatic tissue

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What is the most common type of asbestos to cause asbestosis?

A

Chrysotile

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

True/False. Silicosis may continue to progress even if the patient is removed from the exposure.

A

True

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

These are classic histologic findings in cases of asbestosis.

A

Asbestos bodies/Ferruginous bodies

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

This immunohistologic stain is specific to mesothelioma.

A

Calretinin +

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What is the most common pathologic manifestation of asbestos exposure?

A

Pleural plaques - generally bilateral

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What are the stages of coal workers’ pneumoconiosis?

A

Anthracosis, simple coal workers’ pneumoconiosis, complicated coal workers’ pneumoconiosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What finding is likely to be present on a chest x-ray of a patient with silicosis?

A

Eggshell calcifications and bilateral hilar lymphadenopathy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

A sandblaster presents with respiratory problems. Histologic analysis of lung tissue under polarized light reveals elongated crystalloid structures. What is the diagnosis?

A

Silicosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What histologic findings are characteristic of Berylliosis?

A

Noncaseating, non-necrotizing granulomas and multinucleated giant cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Describe the pathogenesis of silicosis.

A

Macrophages phagocytize silica crystals and stimulate the release of inflammatory mediators. This eventually leads to fibroblast activation and collagen deposition

How well did you know this?
1
Not at all
2
3
4
5
Perfectly