Pathology of Occupational Lung Disease Flashcards
This type of asbestos is more pathogenic and associated with mesothelioma, but is less common.
Amphibole type
True/False. Rounded atelectasis is a life-threatening complication of asbestos exposure.
False - they are clinically benign plaques surrounding atelectatic tissue
What is the most common type of asbestos to cause asbestosis?
Chrysotile
True/False. Silicosis may continue to progress even if the patient is removed from the exposure.
True
These are classic histologic findings in cases of asbestosis.
Asbestos bodies/Ferruginous bodies
This immunohistologic stain is specific to mesothelioma.
Calretinin +
What is the most common pathologic manifestation of asbestos exposure?
Pleural plaques - generally bilateral
What are the stages of coal workers’ pneumoconiosis?
Anthracosis, simple coal workers’ pneumoconiosis, complicated coal workers’ pneumoconiosis
What finding is likely to be present on a chest x-ray of a patient with silicosis?
Eggshell calcifications and bilateral hilar lymphadenopathy
A sandblaster presents with respiratory problems. Histologic analysis of lung tissue under polarized light reveals elongated crystalloid structures. What is the diagnosis?
Silicosis
What histologic findings are characteristic of Berylliosis?
Noncaseating, non-necrotizing granulomas and multinucleated giant cells
Describe the pathogenesis of silicosis.
Macrophages phagocytize silica crystals and stimulate the release of inflammatory mediators. This eventually leads to fibroblast activation and collagen deposition