Clinical Perspective of Pulmonary Hypertension Flashcards

1
Q

What population is most at risk for idiopathic pulmonary hypertension?

A

Young women of child bearing age

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2
Q

What calcium channel blocker is most utilized to treat pulmonary hypertension?

A

Nifedipine

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3
Q

When should IV vasodilators be considered for a patient?

A

A patient who experiences symptoms at rest and has significant impairment of daily activities and/or patients with RV dysfunction

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4
Q

Mutations of this gene are seen in nearly half of all familial cases of pulmonary hypertension.

A

Bone morphogenic protein receptor 2 (BMPR2)

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5
Q

This Group of pulmonary hypertension is due to unclear or multifactorial mechanisms.

A

Group 5

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6
Q

What is the MOA of Bosentan?

A

Endothelin-1 receptor antagonist

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7
Q

What is Group 1 pulmonary hypertension?

A

Pulmonary hypertension due to idiopathic, genetic, drug, or infectious causes.

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8
Q

A patient that develops pulmonary hypertension due to chronic small pulmonary emboli is considered what Group?

A

Group 4

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9
Q

What Group of pulmonary hypertension is due to lung diseases and hypoxia (ex: COPD, sleep apnea, interstitial lung disease)

A

Group 3

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10
Q

These hormones are innate vasodilators.

A

Prostacyclin, nitric oxide

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11
Q

What types of drugs may be utilized to treat Group 1 pulmonary hypertension?

A

Prostanoids, endothelin-1 receptor antagonists, PDE-5 inhibitors, calcium channel blockers, guanylate cyclase stimulators

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12
Q

What is the cause of Group 2 pulmonary hypertension?

A

Left heart disease

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13
Q

This histologic finding is a hallmark of Group 1 pulmonary hypertension.

A

Plexiform lesion

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14
Q

This drug is a PDE-5 inhibitor to treat pulmonary hypertension.

A

Sildenafil

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15
Q

This hormone acts as an innate vasoconstrictor.

A

Endothelin-1

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