Pharmacology of Drugs for URTIs & Pneumonia

Question 1

This antibiotic has been associated with tendon rupture and aortic aneurysms?

Answer 1

Levofloxacin

Question 2

What is the MOA of the empiric treatment for uncomplicated atypical pneumonia?

Answer 2

Azithromycin - binds 50s ribosome to inhibit protein synthesis

Question 3

Why is ritonavir administered with nirmatrelvir?

Answer 3

Ritonavir is a CYP inhibitor, prolonging the half-life of nirmatrelvir

Question 4

What is the MOA of levofloxacin?

Answer 4

Inhibits the topoisomerase to stop DNA synthesis

Question 5

What ADRs are associated with doxycycline?

Answer 5

Phototoxicity, gastric discomfort, chelation with Ca2+

Question 6

What is the recommended treatment for pneumonia due to vancomycin-resistant MRSA?

Answer 6

Linezolid

Question 7

When is imipenem-cilastin indicated to treat pneumonia?

Answer 7

Pneumonia with Klebsiella

Question 8

What is the MOA of the antiviral used to treat influenza?

Answer 8

Oseltamivir - neuraminidase inhibitor

Question 9

This antibiotic is recommended in patients with atypical pneumonia with a beta lactam allergy.

Answer 9

Doxycycline

Question 10

What is the recommended treatment for pneumonia due to MRSA?

Answer 10

Vancomycin

Question 11

What is the indication for levofloxacin in treating pneumonia?

Answer 11

Community acquired pneumonia with comorbidities

Question 12

What ADR is associated with oseltamivir?

Answer 12

Insomnia

Question 13

What is the MOA of nirmatrelvir?

Answer 13

COVID protease inhibitor

Question 14

These antibiotics are recommended in patients with pneumonia due to Pseudomonas.

Answer 14

Cefepime or Piperacillin-Tazobactam

Question 15

What is the MOA of doxycycline?

Answer 15

Binds 30S ribosome to inhibit protein synthesis

Question 16

What ADRs are associated with vancomycin?

Answer 16

Red man syndrome, nephrotoxicity, otoxicity

Question 17

What is the empiric treatment for uncomplicated community acquired pneumonia?

Answer 17

Amoxicillin