Pharmacology (not done) Flashcards
What is the MOA of lidocaine/pramoxine?
Sodium channel antagonist –> interferes with impulse production and action potential in nerves
What is the MOA of capsaicin?
TRPV1 agonist on C nerve fibers –> depolarization and neural desensitization
What is the MOA of topical menthol?
TRPM8 antagonist –> cooling sensation (no major benefits in dogs to date)
What is the MOA of antihistamines?
H1 receptor antagonists –> competitively block formation of histamine-receptor complex
What is the MOA of maropitant for itch?
Neurokinin-1 receptor inhibitor
What is the MOA of lokivetmab?
Anti-canine IL-31 mAB –> binds to circulating IL-31 and prevents it binding to its receptor
What is the MOA of ranevetmab?
Anti-canine nerve growth factor mAB (fails to prevent atopic itch)
What is the MOA of gabapentin and pregabalin?
GABA analog (inhibitory neurotransmitter) –> inhibits voltage-gated Ca channels in spinal cord –> reduces central neural hypersensitization
What is the MOA of topiramate?
NMDA receptor antagonist –> increases GABA activity and inhibits glutamate activity –> less neuronal excitability
What is the antipruritic MOA of butorphanol?
Mixed kappa-opioid agonist and mu-opioid antagonist
Would naloxone be potentially antipruritic?
Yes because it is a mu-opioid antagonist
What is the antipruritic MOA of amantadine?
NMDA receptor antagonist –> less neuronal excitability
What is the MOA of amitriptyline?
Tricyclic SSRI –> inhibits reuptake of serotonin –> increased neural impulses
What is the MOA of clomipramine?
Tricyclic SSRI –> inhibits reuptake of serotonin
(potent SSRI but not very specific)
What is the MOA of fluoxetine?
Bicyclic SSRI–> inhibits reuptake of serotonin
(very selective)
What is the MOA of doxepin?
SNRI –> inhibits reuptake of serotonin and norepi –> increased neurotransmission
Also has potent anti-H1 receptor properties
What is the MOA of mirtazapine?
SNRI –> antagonizes serotonergic and noradrenergic receptors
(useful for nocturnal pruritus)
How does vitamin E help in treatment of SNP?
Reduces damage from lipid peroxidation
What drug has been associated with a drug-induced panniculitis?
KBr
What is the MOA of itraconazole?
inhibits 14alpha demethylase –> prevents conversion of lanosterol to ergosterol
At which pH is oral itraconazole best absorbed?
Acidic (so giving with food helps)
What cutaneous adverse effect has been associated with itraconazole in dogs?
Vasculitis/ulcers (>10 mg/kg dose)
What is the MOA of ketoconazole?
Inhibits lanosterol 14alpha demethylase –> ergosterol depletion, accumulation of toxic sterols in the cell membrane
Which antifungal interferes with endogenous steroid synthesis?
Ketoconazole