Pharmacology for asthma Flashcards
what is clearance?
Clearance is the measure of the ability of the body to eliminate a drug. Clearance by means of various organs of elimination is additive. Elimination of drug may occur as a result of processes that occur in the liver, kidney, and other organs.
what is Elimination half-life?
Elimination half-life is the length of time required for the concentration of a particular drug to decrease to half of its starting dose in the body.
what is time to peak plasma levels
Time to peak concentration is the time required for a drug to reach peak concentration in plasma. The faster the absorption rate, the lower is the time to peak plasma concentration.
where is ACE found?
pulmonary and renal endothelium
effects of ACE
vasoconstriction
salt and water retention
aldosterone secretion
-> if inhibited, bradykinin accumulates which causes a cough
why are ACEi favoured over ARB?
- they’re cheaper
- they’re similarly effective
- ACEi are probably better for cardiovasc risk
things to check if start ACEi
- check eGFR
- serum electrolytes (especially K+)
- blood pressure
