General Surgery in the GI Tract Flashcards

1
Q

What is the general approach to a patient presenting with acute abdominal pain?

A

PC = use SOCRATES for pain assessment

[Site, Onset, Character, Radiation, Association, Time course, Exacerbating/Relieving factors, Severity / Scale)

PMHx, DHx, SHx

Investigations

Management

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2
Q

What are some investigations that could be performed for acute abdominal pain?

A

Investigations ordered depend on the presentation

Bloods: VBG, FBC, CRP, U&Es (urea and electrolytes - renal profile), LFTs + amylase

Urinalysis + Urine MC&S - always do these, many acute abdominal issues come from UTIs

Imaging:

Erect CXR, AXR, CTAP (CT abdo and pelvis), CT angiogram (suspected bleeding or infarction of intraabdominal blood vessel), USS

Endoscopy

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3
Q

What are the management approaches for acute abdominal pain?

A

ABCDE approach - airways, breathing, circulation, disability, exposure

Conservative management

Surgical management

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4
Q

What are the differentials for RUQ / right hypochondriac pain?

A
Bilary Colic
Cholecystitis/Cholangitis
Duodenal Ulcer
Liver abscess
Portal vein thrombosis
Acute hepatitis
Nephrolithiasis
RLL pneumonia

List not exhaustive

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5
Q

What are the differentials for epigastric pain?

A
Acute gastritis/GORD
Gastroparesis
Peptic ulcer disease/perforation
Acute pancreatitis
Mesenteric ischaemia 
AAA (Abdominal Aortic Aneurysm) Aortic dissection
Myocardial infarction

List not exhaustive

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6
Q

What are the differentials for LUQ / left hypochondriac pain?

A
Peptic ulcer
Acute pancreatitis
Splenic abscess
Splenic infarction
Nephrolithiasis
Left Lower Lobe Pneumonia

List not exhaustive

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7
Q

What are the differentials for RLQ / right iliac pain?

A
Acute Appendicitis
Colitis
IBD
Infectious colitis
Ureteric stone/Pyelonephritis
PID/Ovarian torsion
Ectopic pregnancy
Malignancy

List not exhaustive

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8
Q

What are the differentials for suprapubic / central pain?

A
Early appendicitis
Mesenteric ischaemia
Bowel obstruction 
Bowel perforation 
Constipation 
Gastroenteritis
UTI/Urinary retention
PID - pelvic inflammatory disease

List not exhaustive

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9
Q

What are the differentials for LLQ / left iliac pain?

A
Diverticulitis
Colitis
IBD (Inflammatory Bowel Disease)
Infectious colitis
Ureteric stone/Pyelonephritis
PID/Ovarian torsion
Ectopic pregnancy
Malignancy

List not exhaustive

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10
Q

How do patients with bowel ischaemia present clinically?

A

Sudden onset crampy abdominal pain

Severity of pain depends on the length and thickness of colon affected (positive correlation)

Bloody, loose stool (currant jelly stools)

Associated fever, signs of septic shock

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11
Q

What are the risk factors for bowel ischaemia?

A
Age >65 yrs
Cardiac arrythmias (mainly AF) and history of atherosclerosis
Hypercoagulation/thrombophilia
Vasculitis
Sickle cell disease 
Profound shock causing hypotension
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12
Q

What are the 2 types of bowel ischaemia?

A
  1. Acute mesenteric ischaemia

2, Ischaemic collitis

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13
Q

What are the main features of acute mesenteric ischaemia?

A

Small Bowel

Usually occlusive and secondary due to thromboemboli (SMA) - AF (atrial fibrillation) makes this more likely as cardiac arrythmia can throw small clots to block the SMA

Sudden onest (but presentation and severity varies)

Abdominal pain can be out of proportion of clinical signs
e.g. extreme pain but nothing clinically wrong OR something major clinically but patient feels well

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14
Q

What happens if the clot completely occludes / obstructs the SMA?

A

Lose all the bowel from the DJ (duodenojejunal) flexure to the splenic flexure - all the small bowel + 3/4 of large bowel

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15
Q

What are the main features of ischaemic Collitis?

A

Large bowel

Usually due to non-occlusive low flow states or atherosclerosis

More mild and gradual (80-85% of cases)

Moderate pain and tenderness

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16
Q

What investigations should be performed for suspected bowel ischaemia?

A

Bloods =
FBC: neutrophilic leukocytosis (abnormally high number of neutrophils)
VBG (venous blood gases): Lactic acidosis (low pH from build up of lactic acid due to late stage mesenteric ischaemia = dead bowel)

Imagings =
CTAP/CT Angiogram:
Detects - disrupted flow, vascular stenosis, ‘Pneumatosis intestinalis’ (transmural ischaemia/infarction), and Ischaemic colitis: Thumbprint sign (unspecific sign of colitis)

Endoscopy =
For mild or moderate cases of ischaemic colitis (detects oedema, cyanosis, ulceration of mucosa)

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17
Q

What is the conservative management approach to an ischaemic bowel and when is it used?

A

Suitable only for mild to moderate cases of ischaemic collitis (not suitable for small bowel ischaemia)

IV fluid resuscitation
Bowel rest - nil by mouth
Broad-spectrum antibiotics - as colonic ischaemia can result in bacterial translocation and subsequent sepsis
NG tube for decompression - in concurrent ileus
Anticoagulation
Treat/manage underlying cause
Serial abdominal examination and repeat imaging - check for changes(e.g. perotonitis inside the abdomen) / progress of treatment

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18
Q

When is surgical management used for ischaemic bowel?

A

Almost a necessity in most patients

Required in:
Small bowel ischaemia
Signs of peritonitis or sepsis
Haemodynamic instability
Massive bleeding
Fulminant colitis with toxic megacolon
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19
Q

What are the two types of surgical management?

A

Exploratory laparotomy =
Explore everything from the DJ flexure to the rectum
Resect necrotic bowel with or without open surgical embolectomy (baloon catheter in SMA) or mesenteric arterial bypass

Endovascular revascularisation =
Balloon angioplasty/thrombectomy
In patients without signs of ischaemia

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20
Q

How does acute appendicitis present clinically?

A

Initially periumbilical pain that migrates to RLQ (within 24hours)

Usually associated with anorexia, nausea +/- vomiting, low grade fever, change in bowel habit (due to inflamed appendix located next to the rectum, irrtating it, hence altering the bowel habit)

Good way to test for anorexia - ask to get them a meal, if they refuse, likely to be appendicitis

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21
Q

What are the important clinical signs in acute appendicitis?

A

McBurney’s point = usually where the appendix lies (lateral 1/3 of a hypothetical line drawn from the right ASIS to the umbilicus), tenderness in the RLQ

Blumberg sign = rebound tenderness especially in the RIF (right iliac fossa) - press down and suddenly release = patient suddenly jump

Rovsing sign = RLQ pain elicited on deep palpation of the LLQ - press down on the left iliac fossa but they report pain in the right iliac fossa due to moving of the perotineum causing irritation on the other side

Psoas sign = RLQ pain elicited on flexion of right hip against resistance

Obturator sign = RLQ pain on passive internal rotation of the hip with hip & knee flexion

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22
Q

What investigations should be carried out for suspected acute appendicitis?

A

Bloods =
FBC: neutrophilic leukocytosis
Increased CRP
Urinalysis: possible mild pyuria / haematuria
Electrolyte imbalances in profound vomiting

Imaging =
CT: gold standard in adults esp. if age > 50
USS: children/pregnancy/breastfeeding
MRI: in pregnancy if USS inconclusive

Diagnostic laparotomy = only used in persistent pain and inconclusive imaging

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23
Q

What is the diagnostic tool used for acute appendicits?

A

Alvardo score = consists of 6 clinical items:
(brackets represent points awarded for each sign)

RLQ Tendereness (2)
Fever (1)
Rebound tenderness (1)
Pain migration (1)
Anorexia (1)
Nausea +/- vomiting (1)
WCC > 10,000 (2)
Neutrophilia (left shift) (1)

≤4 Unlikely
5-6 Possible
≥7 Likely

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24
Q

What is the conservative management for acute appendicitis?

When do you use conservative management?

A

Conservative Management =
IV Fluids, Analgesia, IV or PO Antibiotics
In abscess, phlegmon or sealed perforation - resuscitation + IV antibiotics +/- percutaneous drainage

Only used when =
After negative imaging in selected patients with clinically uncomplicated appendicitis
Usually when patient presents late with mass/abscess/phlegmon formation in their RIF (right iliac fossa) = CT-guided drainage and IV antibiotics as surgery to now take appendix out is a major undertaking so it is far better to treat conservatively

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25
Q

What is an interval appendicectomy and why is it used after conservative management of acute appendicitis?

A

Take out appendix electively on a scheduled date

Although late presentations are treated conservatively initially due to risk of surgery complications

After consevative management, most patients are later revisted with an interval appendicectomy as rate of recurrence after conservative management of abscess/perforation is 12-24%, so appendix is taken out later electively before it causes further issues

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26
Q

What are the benefits of laparoscopic over open appendicectomy ?

A
Less pain
Lower incidence of surgical site infection
Decreased length of hospital stay
Earlier return to work
Overall costs 
Better quality of life scores

Most patients are home the next day = quick recovery time

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27
Q

What are the steps of laparoscopic appendicectomy?

A

Trocar placement (usually at 3 port sites)

Exploration of RIF & identification of appendix
Elevation of appendix + division of mesoappendix (containing artery)

Based secured with endoloops and appendix is divided - so first you mobilise the appendix, then you lasso around the base and tighten

Retrieval of appendix with a plastic retrieval bag - to avoid infection spreading in the abdo cavity and port site

Careful inspection of the rest of the pelvic organs/intestines

Pelvic irrigation (lavage / wash out) + Haemostasis

Removal of trocars + wound closure

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28
Q

What is bowel / intestinal obstruction?

A

Restriction of normal passage of intestinal contents

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29
Q

What are the 2 main groups of intestinal obstruction?

A
  1. Paralytic (adynamic) ileus - occurs when the abdomen is full of pus that irritates the bowel, the bowel stops peristalsis and this does not get better until the infection is gone
  2. Mechanical - a physical obstruction causing fluids and waste to build up in the portion of the bowel prior to the obstruction
30
Q

What are the 4 components to classifying a mechanical intestinal obstruction?

A
  1. Speed of onset
  2. Site
  3. Nature
  4. Aetiology
31
Q

What of each of the components below highlight about the mechanical intestinal obstruction?

  1. Speed of onset
  2. Site
  3. Nature
  4. Aetiology
A
  1. Speed of onset = acute, chronic or acute-on-chronic
  2. Site = high or low
    - Roughly synonymous with small or large bowel obstruction
  3. Nature = simple VS strangulation
    - Simple = bowel occulded without damage to blood supply (bowel still perfused and healthy)
    - Strangulation = blood supply of involved segment of intestine is cut off (e.g. in strangulated hernia, volvulus, intussusception - e.g. a polyp that is taken down by peristalsis causing the bowel to turn inside out like the sleeve of a jacket)
  4. Aetiology =
    - Causes in the lumen = faecal implantation, gallstone ‘ileus’ (gallstone erodes through the gallbladder into the bowel)
    - Causes in the wall = Crohn’s disease, tumours, diverticulitis of colon
    - Causes outside the wall - strangulated hernia (external or internal), volvulus, obstruction due to adhesions or bands
32
Q

What are the main causes of small bowel obstruction?

A

Adhesions (60%) - patient usually has PMH of previous abdominal surgery

Neoplasia (20%) - primary (rare), metastatic or extraintestinal e.g. can happen in ovarian peritoneal disease with peritoneal deposited tumour can catch a part of the small bowel

Incarcerated hernia (10%) - external (Within abdominal wall) or internal (mesenteric defect)

Crohn’s disease (5%) - acute (oedema) or chronic (strictures)

Other (5%) - intussusception, intraluminal (foreign body, bezoar)

33
Q

What are the main causes of large bowel obstruction?

A

Colorectal cancer - usually occurs on left hand side to cause obstruction as on the right hand side a small tumour can be compensated by bowel expansion and so will require a significantly larger tumour

Volvulus - twist of the bowel on itself like a balloon at the sigmoid or caecal part of the colon

Diverticulitis - inflammation, strictures

Faecal impaction -

Hirchsprung disease - birth defect and commonly presents in infants / children, characterised by absence of nerve cells / ganglions in a sengment of the bowel, so that part of the bowel cannot carry out peristalsis leading to long term obstruction

34
Q

What are the 4 main signs of a patient presenting with a bowel obstruction?

A

Abdominal pain
Vomiting
Abdolute constipation
Abdominal Distension

35
Q

How do patients present clinically with small bowel obstruction?

A

Abdominal pain = colicky, central pain

Vomiting = early onset vomiting (i.e. the higher up the obstruction, the wuicker the vomiting starts due to fluid build up) - large amount and bilious

Absolute constipation = late sign, as everything in the large bowel can still come through

Abdominal distention = less significant

36
Q

How do patients present clinically with large bowel / colon obstruction?

A

Abdominal pain = colicky or constant pain

Vomiting = late onset - the back pressure needs to travel up most of the GI tract to initiate comiting - initally billous progress to faecal vomiting (i.e. what they’re vomiting looks a lot like faeces

Absolute constipation = early sign

Abdominal distention = early sign and significant

37
Q

What are some other signs patients with any type of bowel obstruction present with clinically?

A

Other signs =

Dehydration - from the vomiting

Increased high pitched tinkling bowel sounds (early sign), or absent bowel sounds (late sign due to stopping of peristalsis)

Diffuse abdominal tenderness - intervene asap

38
Q

What are the three important factors for diagonisisng bowel obstruction?

A

Diagnosed by the presence of symptoms

Examination should always include a search for hernias and abdominal scars (looking for strangulated bowel), including laparoscopic portholes

Is it simple (viable bowel) or strangulating (non-viable bowel = faster intervention required)?

39
Q

What features suggest it is a strangulation rather than a simple obstruction?

A

Change in character of pain from colicky to continuous

Tachycardia

Pyrexia

Peritonism - localised inflammation of the peritoneum

Bowel sounds absent or reduced

Leucocytosis

Increased C-reactive protein

40
Q

What is the mortality rate of strangulating obstruction with peristonitis?

A

Up to 15%

41
Q

What are common hernial sites?

A

Epigastric

Umbilical

Incscional - from previous operation, skin has healed but muscle below has a defect so bowel can come through that

Inguinal - at the groin, usually defects in the abdominal wall

Femoral

42
Q

What is most important about the defect causing the hernia?

A

Size
Large defect = bowel can go in and out without any problems
The smaller the hole, the greater the chance of the hernia obstructing and strangulating

43
Q

What are the 3 different types of hernia?

A

Neck of sac

Strangulated hernia = compromised blood flow, venous return is first to go, so as blood stops going out, it compresses the arterial blood coming in leading to ischaemic bowel

Richter’s hernia = just a small amount of bowel caught, so there is still continuity of the small and large bowel but there is that small portion of ischaemic bowel that needs to be removed

44
Q

What are the investigations that can be carried out for a suspected bowel obstruction?

A

Bloods =
WCC/CRP = usually normal (if raised suspicion of strangulation / perforation)

U&E = electrolyte imbalance from vomiting

VBG (venous blood gas) from vomiting shows HypoCl- (hypochloraemic), HypoK+ (hypokalaemia) = metabolic alkalosis

VBG if strangulation = metabolic acidosis (lactate)

Imaging =
Erect CXR / AXR (chest / abdominal x-ray)
- SBO (small bowel obstruction) = Dilated small bowel loops >3cm proximal to the obstruction (central)
- LBO (large bowel obstruction) = dilated large bowel >6cm (if caecum >9cm) predominantly peripheral

CT abdo/pelvis = shows transition point (helpful for surgery), dilatation of proximal loops – IV or oral contrast if possible

45
Q

What does a small bowel obstruction on an abdominal x-ray show?

A

Ladder pattern of dilated loops & their central position (easier to see on supine than erect xray)

Striations that pass completely across the width of the distended loop produced by the circular mucosal folds

46
Q

What does a large bowel obstruction on an abdominal x-ray show?

A

Distended large bowel tends to lie peripherally (easier seen on erect xray)

Show haustrations of taenia coli - do not extend across whole width of the bowel.

47
Q

What information can CT scans show regarding bowel obstructions?

A

Can localize site of obstruction

Detect obstructing lesions & colonic tumours

May diagnose unusual hernias (e.g. obturator hernias).

48
Q

What are the 3 types of management for a bowel obstruction?

A

Supportive
Conservative
Surgical

49
Q

What is the supportive mangement for bowel obstruction?

A

NBM (nil by mouth), IV peripheral access with large bore cannula - IV Fluid resuscitation (basic rate depends on weight)

IV analgesia (For colicky pain), IV antiemetics, correction of electrolyte imbalances

NG tube for decompression (vital for removing chance of aspiration pneumonia), urinary catheter for monitoring output (influences IV fluid replacement)

Introduce gradual food intake if abdominal pain and distension improve

50
Q

What do you need to be careful of for small bowel obstruction with the commonest cause is secondary to adhesions?

A

The more fluid you pump into it, the more it twists on that area = worsening of obstruction

51
Q

What is the conservative treatment for bowel obstruction?

A

Faecal impaction = stool evacuation (manual, enemas, endoscopic)

Sigmoid volvulus: rigid sigmoidoscopic decompression - pass tube through bowel and suck all the fluid out causing it collapse, giving it a chance to straighten it out

SBO: oral gastrograffin (highly osmolar iodinated contrast agent) can be used to resolve adhesional small bowel obstruction

52
Q

When is surgical management used, and what are the indications of surgical management for bowel obstruction?

A

Used when bowel obstruction does not resolve OR patient has developed signs of ischaemia

Haemodynamic instability or signs of sepsis
Complete bowel obstruction with signs of ischaemia
Closed loop obstruction - intervene quicly before it becomes ischaemic e.g. strangulated hernia
Persistent bowel obstruction >2 days despite conservative management

53
Q

What are the surgical management operation options available?

A

Exploratory Laparotomy / Laparoscopy - find the cause and remove it, ensure all bowel left is viable

Restoration of intestinal transit (depending on intra-operational findings)

Bowel resection with primary anastomosis or temporary/permanent stoma formation (when it is not safe to join the 2 ends of the bowel straight away after the resection of the non-viable bowel)

54
Q

What is endoscopic stenting and when is it used?

A

Non-surgical management of distal obstruction - stend placed endoscopically to prevent constriction or collapse of tubular organ

Reserved for patients with tumours

55
Q

How does GI perforations present clinically?

A

Sudden onset severe abdominal pain associated with distention

Examination shows diffuse abdominal guarding, rigidity, rebound tenderness

Pain aggravated by movement

Nausea, vomiting, absolute constipation (due to ileus i.e. irritation of chemicals of the bowel rather than mechanical obstrution)

Fever, Tachycardia, Tachypnoea, Hypotension

Decreased or absent bowel sounds

56
Q

What are the 4 main perforations of the GI tract?

A

Perforated peptic ulcer
Perforated diverticulum
Perforated appendix
Perforated malignancy

57
Q

What are the features of perforated peptic ulcer?

A

Sudden epigastric or diffuse pain

Referred shoulder pain - diaphragm irritation - as phrenic nerve innervates shoulder

HPC / PMH of NSAIDs, steroids, recurrent epigastric pain

58
Q

What are the features of perforated diverticulum?

A

LLQ pain

Constipation

59
Q

What are the features of perforated appendix?

A

Present a phlemons (inflammation of soft tissue under skin)
Migratory pain
Anorexia
Gradual worsening RLQ pain

60
Q

What are the features of perforated malignancy?

A
HPC of:
Change in bowel habit
Weight loss
Anorexia
PR Bleeding
61
Q

What are the investigations carried out for a suspected GI perforation?

A

Bloods =
FBC = neutrophil leukocytosis

Possible elevation of urea and creatinine (checking renal function)

VBG (venous blood gas) = lactic acidosis

Imaging =
Erect CXR =
- Subdiaphragmatic free air (pneumoperitoneum)

CT abdo/pelvis
- Pneumoperitoneum, free GI content, localised mesenteric fat stranding
can exclude common differential diagnoses such as pancreatitis

62
Q

What other conditions can present as a GI perforation (i.e. what else would be on your differential diagnoses?)

A

Acute cholecystitis
Appendicits
MI
Acute pancreatitis

63
Q

What is the supportive / conservative management given to the patient on presentation of a suspected GI perforation?

A
NBM & NG tube
IV peripheral access with large bore cannula - IV Fluid resuscitation
Broad spectrum antibiotics
IV PPI
Parenteral analgesia & antiemetics
Urinary catheter
64
Q

What is the conservative management for GI perforation presentation without sepsis?

A

Conservative management in localised peritonitis without signs of sepsis = very rare

IR - guided drainage of intra-abdominal collection

Serial abdominal examination and abdominal imaging for assessment - look for any changes, and do not hestitate to shift management to surgical

But most people require an operation

65
Q

What are the stages of surgical management for GI Perforation with generalised perotonitis with/without signs of sepsis?

A

Exploratory laparotomy/laparascopy

Primary closure of perforation with or without omental patch (most common in perforated peptic ulcer)

Resection of the perforated segment (e.g. in a perforated diverticulum) of the bowel with primary anastomosis or temporary stoma

Obtain intra-abdominal fluid for MC&S (microscopy culture and sensitivity), peritoneal lavage

If perforated appendix: Lap or open appendicectomy

If malignancy: intraoperative biopsies if possible

66
Q

What are some common biliary and pancreatic causes of an acute abdomen?

A

Biliary Colic
Acute Cholecystitis
Acute Cholangitis
Pancreatitis

67
Q

What are the symptoms, investigations and management options for biliary colic?

A

Symptoms =
Postprandial RUQ pain with radiation to the shoulder.
Nausea

Investigations =
Normal blood results
USS: cholelithiasis (often people already know they have gallstones)

Management =
Analgesia, Antiemetics, Spasmolytics
Follow up for elective cholecystectomy

68
Q

What are the symptoms, investigations and management options for acute cholecystitis?

A

Symptoms =
Acute, severe RUQ pain
Fever
Murphy’s sign

Investigations =
Elevated WCC/CRP
USS: thickened gallbladder wall

Management =
Fluids, ABx, Analgesia, Blood cultures
Early (<72 hours) or elective cholecystectomy (4-6 weeks)

69
Q

What are the symptoms, investigations and management options for acute cholangitis?

A

Symptoms =
Charcot’s triad: jaundice, RUQ pain, fever

Investigations =
Elevated LFTs, WCC, CRP, Blood MCS (+ve)
USS: bilary dilatation

Management =
Fluids, IV antibiotics, Analgesia
ERCP (within 72hrs) for clearance of bile duct or stenting

70
Q

What are the symptoms, investigations and management options for pancreatitis?

A

Symptoms =
Severe epigastric pain radiating to the back
Nausea +/- vomiting
Hx of gallstones or EtOH use

Investigations =
Raised amylase/lipase
High WCC/Low Ca2+
CT and US to assess for complications/cause - only useful after a few weeks when there are changes

Management = 
Admission score (Glasgow-Imrie)
Aggressive fluid resuscitation, O2
Analgesia, Antiemetics
ITU/HDU involvement