Pharmacology: Drug and asthma Flashcards
Anti-histamines are not bronchiodilators
True or false?
True
Which steroid is administered orally in more severe forms of asthma and exacerbations of COPD?
prednisolone
fluticasone
ipratropium
hydrocortisone
prednisolone
Which of the following drugs is a bronchodilator used in the relief of an acute attack of asthma?
salmeterol
fluticasone
salbutamol
theophylline
salbutamol
Which drug is a B2 adrenoceptor agonist delivered by inhalation in the maintenance therapy of asthma?
terbutaline
salmeterol
bambuterol
fluticasone
salmeterol
Therapeutic monoclonal antibodies, useful in treating severe eosinophilic asthma, neutralise which of the following mediators?
Lipocortin
Leukotrienes
Adenosine
Interleukin-5
Interleukin-5
A 47 year old man has been admitted to the respiratory ward with an acute exacerbation of asthma. Despite treatment with nebulised salbutamol and ipratropium he remains symptomatic and is started on an infusion of aminophylline. Which test would be best to check for signs of aminophylline toxicity?
respiratory rate
oxygen saturation
serum theophylline
blood pressure
serum theophylline
Which of the following adverse drug effects is most likely to occur following treatment with theophylline?
cardiac arrhythmias
dry mouth
muscle tremor
oral candidasis
cardiac arrhythmias
Which of the following statements is most appropriate concerning the use of fluticasone delivered via a metered dose aerosol?
allows the maintenance dose of oral prednisolone can be reduced
more of the administered dose enters the lung than is swallowed
a dose of 2mg/day does not suppress the hypothalamic-pituitary axis
fluticasone has a higher systemic bioavailability than prednisolone
allows the maintenance dose of oral prednisolone can be reduced
A 20 year old woman, diagnosed with asthma 6 months ago, has been using a salbutamol inhaler 0.1mg, 2 puffs every 12 hours. She has allergic rhinitis and eczema, managed by oral cetrizine 10mg and various topical agents. She reports worsening of her nocturnal cough and tremor which has developed over the last month together with a 25% drop in peak expiratory flow. The cough has responded to an increased use of the inhaler. Select the most appropriate treatment option to manage her asthma.
increase the salbutamol inhaler to 2 puffs, 6 hourly
stop the salbutamol inhaler
add a steroid inhaler
add a steroid inhaler + counsel about salbutamol over use
add a steroid inhaler + counsel about salbutamol over use
A 21 year old patient is admitted with 8 hours of severe breathlessness. He has just started smoking and has a previous history of asthma. His only medication is a salbutamol inhaler which is providing little benefit. His expiratory peak flow is 280mL/min (best 620mL/min).On examination a widespread polyphonic wheeze is detected throughout his chest. His respiratory rate is 32/min, SaO2 is 80% on air and he has just begun to receive oxygen. Which would be the first drug regimen to be prescribed to improve the dyspnoea?
oral prednisolone
corticosteroid inhaler
nebulised salbutamol
salmeterol inhaler
nebulised salbutamol
Which of the following potential adverse effects may be associated with the chronic use of oral B2-adrenoceptor agonists in asthma therapy?
induction of labour
dry mouth
oral candidasis
hypokalaemia
Hypokalameia
