Pharmacology

Question 1

which layer in the epidermis is selectively-permeable?

Answer 1

stratum corneum (keratin layer)

Question 2

what are the different types of topical medications and what they’re used for?

Answer 2

emollients: dry/scaly conditions
steroids: anti-inflammatory
calcineurin inhibitors: suppress lymphocyte activity
antiseptic: kill bacteria
antivirals
antifungals
antipruritic
keratolytics: used to soften keratin

Question 3

what is Fick’s law of diffusion?

Answer 3

relationship between diffusion and 3 factors that affect diffusion
- proportional to surface area and concentration difference and inversely proportional to thickness of membrane

Question 4

what is the equation for Fick’s Law?

Answer 4

J= KpCv

where Kp= permeability coefficient and Cv is concentration of drug in vehicle

Question 5

how do glucocorticoids work?

Answer 5

signal via class 1 nuclear receptors causing dissociation of inhibitory heat shock proteins

Question 6

other than tropical tx, what 2 other ways can drugs be administered in derm?

Answer 6

subcutaneous and transdermal (best suited for LMW drugs)