Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Dermatology > Drug Eruptions > Flashcards

Drug Eruptions Flashcards

You may prefer our related Brainscape-certified flashcards:
Dermatology Board Prep flashcards
1
Q

what are the 2 types of drug eruptions?

A

allergic (non-dose dependent) and non-allergic (dose dependent)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

morphologies of drug reactions

A

exanthematous- pigmentation
urticarial- itch/pain
papulosquamous- photosensitivity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

characteristic presentation

A

new medication with symmetrical skin eruption

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

ix and mx for drug eruptions

A

hx and exam, patch test, biopsy

mx- stop meds, topical steroids, antihistamines

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

epi of exanthematous drug reaction (EDR)

A

most common, 4-21 days after drug onset

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

pathophysiology of Exanthematous Drug eruption.

A

t-cell mediated type 4 HS reaction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

aetiology of EDR

A

penicillin, sulphonamides, erythromycin, streptomycin, allopurinol, anti-epileptics, NSAIDs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

s/s of EDR

A

widespread symmetrical morbilliform rash, pruritus, mild fever. starts in torso and spreads to limbs and face.
severe cases- mucosal membranes, face-facial erythema and oedema

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

mx of EDR

A

self-limiting (1-2 weeks)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

which 2 drug types cause an IgE mediates T1 HS reaction and what is this drug reaction called

A

urticarial drug reaction

  • b-lactam abx
  • direct mass cell degranulation (NSAIDs, opiates, aspirin)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

acneiform skin reaction are caused by…

A

steroids

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

ACEI, penicillin and furosemide may cause…

A

bullous disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

what is a fixed drug reaction

A

patches that occur at same site each time drug is taken

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

which drugs cause a fixed drug reaction

A

tetracyclines, paracetamol, NSAIDs, carbamezapine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

s/s of fixed drug reactions

A

well demarcated, red painful lesions at hands, genitilia, lips

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

mx of fixed drug reactions

A

self resolves with hyper pigmentation

17
Q

what are 4 severe cutaneous drug reactions?

A

stevens johnson syndrome
drug reaction with eosinophilia & systemic symptoms (DRESS)
acute generalised exanthematous pustulosis
phototoxic drug reactions

18
Q

what is Stevens Johnson syndrome and toxic epidermal necrolysis

A

severe mucocutaneous disorders that are potentially life threatening. characterised by varying extents of blistering/ eidermal detachment and mucosal ulceration

19
Q

initial symptoms of Stevens Johnson

A

malaise, fever, tender areas of maculopapular erythema on torso with inflammation of mucosa

20
Q

characteristic symptoms of Stevens Johnson that differ from toxic epidermal necrolysis

A

SJS: hands and feet
TEN: widespread flaccid blisters form with skin that wrinkles on gentle pressure (Nikolosky’s)

21
Q

what is ‘skin that wrinkles on gentle pressure’ called

A

Nikolosky’s sign

22
Q

tx of SJS/TEN?

A

high dose steroids, cyclosporin and IV IGs

23
Q

what score is given for prognosis of SJS/TEN?

A

SCORTEN system

24
Q

morbidity of SJS/TEN?

A

systemic issues- renal impairment, hypotension, sepsis, multi organ failure

25
Q

what is DRESS?

A

2-6 weeks after drug exposure and results in widespread erythema, facial oedema, fever, lymphadenopathy, hepatosplenomegaly

26
Q

ix findings for DRESS

A

inc eosinophilia and inc hepatic transferases

27
Q

mx for DRESS

A

oral steroids for 3 months

28
Q

prognosis of DRESS

A

mortality is 10%

29
Q

acute generalised exanthematous pustulosis (AGEP) aetiology?

A

ca channel blockers, some abs

30
Q

s/s of AGEP?

A

exanthem with numerous small non follicular sterile papules around neck, axilla and groin

31
Q

AGEP resolution?

A

with peeling

32
Q

main drugs that cause phototoxic drug reactions

A

doxycycline, amiodarone, quinine, chlorpromazine

33
Q

s/s of PDRs?

A

immediate prickling with delayed erythema & pigmentation, exaggerated sunburn, skin fragility

Dermatology (14 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions