Immunology

Question 1

what are the 4 factors affecting skin immunology?

Answer 1

structure, cells, chemical signals, genetics

Question 2

which elements of the skin’s structure help defend it?

Answer 2

tough layer formed by keratinocytes and corneocytes

Question 3

we know that the epidermis has langerhans cells and T cells that defend it, but what are langerhans cells?

Answer 3

type of dendritic cell characterised by Birbeck granule (tennis racket shaped organelles)

Question 4

T/F: both CD8+ and CD4+ cells are found in the epidermis

Answer 4

F: only CD8+ in epidermis and both found in dermis

Question 5

6 immune cells in the dermis…

Answer 5

dendritic cell (dermal and plasmacytoid) 
macrophages 
mast cells 
NK cells 
T cells 
neutrophils

Question 6

the 2 classes of chemical signalling are…

Answer 6

class 1 (MHC)= all nucleated cells, present to CD8+ - cytotoxic Ts

class 2 (MHC)= on APCs, CD4+- helper Ts

Question 7

what genetic element contributes to immunity…

Answer 7

hypersensitivity (T1-T4)

Question 8

allergy is a T_ hypersensitivity

Answer 8

T1- IgE mediated

Question 9

T/F: contact dermatitis is a non-allergic reaction

Answer 9

T: as it is not mediated by IgE. usually T4 HS reaction- delayed, antigen-specific T cell mediation

Question 10

mx for allergic reactions?

Answer 10

allergen avoidance, anti-histamines, corticosteroids, adrenaline injection, mast cell stabilisers