pharmacology

Question 1

what are the 2 groups of cytotoxic chemo agents

Answer 1

cell cycle specific

non cell cycle specific

Question 2

what is the differnce between cycle specific and non cycle specific in terms of dose and duration

Answer 2

cell cycle - duration more important than dose

non - cell cycle- dose more imporatnt than duration

Question 3

what are the 2 groups of cell cycel specific cytotoxic agents

Answer 3

antimetabolites

mitotic spindle inhibitors

Question 4

examples of antimetabolites

Answer 4

methotrexate
hydroxycarabamide
fludarabine / 6-mercaptopurine

Question 5

side effects of anti-metabolites

Answer 5

myelosuppression

Question 6

examples of mitotic spindle inhibitors

Answer 6

vinca alkaloids eg vinacristine/vinblastine

taxanes- docetaxel,taxotere

Question 7

side effects of vinca-alkaloids

Answer 7

neuropathy

Question 8

give the 3 groups of non cell cycle specific agents

Answer 8

alkylating agents - chlorambucil/melphatan
platinum based- cisplatinum, carboplatin
cytotoxic antibiotics - anthracyclines eg doxorubicin

Question 9

side effects of anthracycline

Answer 9

cardiotooxicity/myopathy

Question 10

side effects of platinum based

Answer 10

nephrotoxicity

ototoxicty id cisplatinum

Question 11

side effcets of alkylating agents

Answer 11

infertility and secondary malignancy

Question 12

what do people get given alongside chemo as prophylaxis

Answer 12

anti-fungals