haemolysis

Question 1

what antibodies is responsible for immediate alloimmune heamolysis and what for delayed alloimmune haemolysis? where does each kind take place

Answer 1

immediate - IgM - intravascular

delayed - IgG - extravascular

Question 2

what test can detect autoimmune haemolysis

Answer 2

direct coombs test

Question 3

what breakdown products are seen in extravascular haemolysis? what linical would this look like

Answer 3

unconjugated bilirubin(pre hepatic) - jaundice and gall stones 
urobiliongenuria -seen in urine

Question 4

what breakdown products are seen in intravascular haemolysis? what is seen clinically

Answer 4

haemoglobinaemia - free Hb in circulation
methaemalbuminaemia - hb combined with albumin
haemaglobuinuria - pink urine then turns black
haemosiderinuria - iron complex

Question 5

what antibodie is involved in warm autoimmune haemolysis ? and when is it seen

Answer 5

IgG

idiopathic, lupus, lymphoproliferative diseases , penecillin and infection

Question 6

what antibodies are produced in cold autoimmune haemolysis ? what is associated with it

Answer 6

igM
EBV and lymphoma

raynauds seen

Question 7

what should be given in herediatry spherocytosis

Answer 7

folate

Question 8

what is the role of G6PD? what is seen on blood film in deficiency

Answer 8

responsibel for creatign glutatione which stops free radical production
heinz bodies

Question 9

causes of intravascular haemolysis

Answer 9

mechanical heart valve 
DIC
HUS
TTP
paroxysmal nocturnal/cold hamoglobinuria 
trasfusion incomaptibility

Question 10

what antibody is involved in parxysmal nocturnal haemoglobinuria

Answer 10

IgG

Question 11

what would an alloimmune haemolysis be in response to

Answer 11

blood transfusion - ABO incompatibility