iron Flashcards
where is most iron used in the body
in haemoglobin
where is iron absorbed
duodenum
what reduces ferric (Fe3+) to ferrous (Fe2+)
cytochrome B
what transporters are involved in iron absorption
DMT - 1
ferroportin
where is hepcidin produced
liver
explain how anaemia of chronic disease occurs
hepcidin produced in inflammation and stop absorption of iron
increasd transcription of ferritin mRNA stimed by inflam cytokines so increased ferritin
how does hepcidin work
causes ferroportin degradation
what trasnports iron in the blood
transferrin
what is iron stored as
ferritin
how many mg of iron normally found in the body
4mg
how many binding sites does transferrin have for iron
2
what is normal transferrin saturations
<50%
what is holotransferrin and apotransferrin - which is bound
holotransferrin - bound
apotransferrin - unbound
breakdown of what casues bilirubin
porphyrin
what are primary and secondary causes of iron overload
primary - haemachromotosis
secondary - trasnfusions , iron loading anaemias
