basics Flashcards
which kind of granulocyte is bi-lobed
eosinophil
which granulocytes has granules that contain histamine
basophils
how many globular proteins does haemoglobin contain
4 - tetramer
contents of a heme group
iron and porphyrin ring
each molecule of iron binds how many molecules of oxygen
1 to 1 ration
breakdown of porphyrin ring produces what
bilirubin
what reacts with hydrogen peroxide in a RBC to form water and stop oxidative damages
glutathione
what enzyme is involved in preventing oxidative damage to the RBC
glucose-6-phosphate dehydrogenase
G6PD
how is G6PD deficient inherited
x-linked recessive
how is the majority of carbon dioxide transported in th blood
60% travels as bicarbonate
what other ways is carbon dioxide transported in the blood
dissolved
bound to Hb as carbamino-Hb
(travels as bicarbonate )
what transporter is involved in co2 transport at the tissue and lung
HCO3- and Cl- transporter
what shape is the haemoglobin dissociation curve
sigmoidal
what kind of binding does Hb express for O2 and what does this mean
CO-OPERATIVE BINDING
when a oxygen molecule binds to Hb the shape changes and altered how easy it is for another molecule to bind
what does it mean when the oxygen dissociation curve shifts to the right
more o2 delivered to tissues as hb has decreased affinity for it and more offloaded
