bleeding disorder Flashcards
causes of thrombocytopenia
DIC, ITP, hypersplenism, marrow destrucion (usually pancytopenic)
What is the most common cause of acquired thrombocytopenia
Immune thrombocytopenic purpura
inheritance of VW
autosomal dominant
what can cause platelets functional defects
drugs eg aspirin, NSAIDs
renal failure - uraemic
causes of secondary haemostasis failure and examples
single factor deficient eg haemophilia
multiple eg DIC liver failure, vit k deficiency, warfarin therapy
in DIC / liver failure what would you expect APTT at PTT to look like
both prolonged
where are clotting factors synthesised (what cell)
hepatocytes
what foods is vitamin k found in
leafy green veg
causes of vitamin k deficiency
poor diet malabsorption obstructive jaundice warfarin haemorrhagic disease of the newborn - all babies give IM vit k at birth
causes of dic
obstetric emergencies, sepsis, malignancy, hypovolaemic shock
anything that causes major tissue damage
treatment of DIC
treat underlying and replace factors eg transfusion
what marker would be increased in haeophilia
APTT
inheriance of haemophilia
x- linked
what factors are deficient in haemophilia A and B
A - 8
B- 9 (christmas disease)
how to treat haemophilia
clotting factor injections
