Pharmacology Flashcards
1
Q
What are routes of absorption?
A
- Enteric coated = intestinal absorption
- Extended release = slower absorption
- Sublingual = buccal avoid 1’st metabolism
2
Q
What are the pharmacokinetics?
A
- What the body does to the the drug.
3
Q
What is absorption?
A
- Passive/facilitated diffusion, active transport, endocytosis
4
Q
What factors affect absorption?
A
- pH, vascularity, surface area, with food (slower emptying)
5
Q
What is bioavailability?
A
- Rate and extent to which the drug reaches systemic circulation.
- IV is 100%
- Factors affecting this include first pass metabolism (liver - drug inactive), solubility, chemical instability.
6
Q
What is distribution?
A
- Drug enters the blood stream and then passes into the extracellular fluid and tissues.
- Factors affecting including blood flow, capillary permeability, plasma/tissue protein binding and liphilicty.
7
Q
What is metabolism?
A
- Process of elimination
- First order = rate of metabolic is proportional to drug conc
- Zero order is where the enzyme statured by higher dose
