Pharmacology

Question 1

Why do children have different response to medication?

Answer 1

Different age
Size
Nutrition
Growth
Especially important in neonates

Question 2

Are pharmacokinetics and pharmacodynamics altered in children?

Answer 2

Yes

Question 3

What are challenges in delivering medicine safely and effectively to children?

Answer 3

Lack of acute dosage data
Lack of appropriate formulations allowing accurate dosage - suspensions
Difficulty in detecting ADRs

Question 4

What is phocolemia?

Answer 4

Flipper limbs

Question 5

What is off label medicine?

Answer 5

Medicine licensed for human use but not in children under 16

Question 6

What are unlicensed medicines?

Answer 6

No licence for human use in this country - includes licensed medicine which has been reformulated for children

Question 7

What are different types of off-label/unlicended prescriptions?

Answer 7

Drug administered via a different route
Medicine used for indication which it is not intended
Used at a different dose to recommended
Children below stated recommended age limit