Pharmacology Flashcards
Where is most Na reabsorbed?
PCT (67%)
SGLT2 inhibitors inhibit reabsorption of what and where?
Glucose in PCT = glucose in urine
Uricosuric drugs
Promote excretion of uric acid into urine or prevent reabsorption of uric acid
Treat gout
4 Starling forces
Capillary hydrostatic pressure
Capilary oncotic pressure
IF hydrostatic pressure
IF oncotic pressure
Disease states that increase _____ or decrease ______ cause oedema
Increase capillary hydrostatic pressure
Decrease capillary oncotic pressure
Causes of oedema
Nephrotic syndrome
Congestive HF
Hepatic cirrhosis with ascites
Sign of proteinuria
Frothy urine
Congestive HF arises from:
Reduced CO = hypovolaemia = activates RAAS
Ascites arises from:
Increased HPV pressure, decreased albumin (oncotic pressure) = oedema and activates RAAS
Which diuretics act on PCT?
CA inhibitors
Where is next 25% of Na reabsorbed?
Thick ascending LOH
Where is last 10% of Na reabsorbed?
DCT
Is thick ascending LOH permeable or impermeable to water?
Impermeable
What do CA inhibitors block?
Na/H exchange in PCT and DCT
Which diuretics act on thick ascending LOH?
Loop diuretics
What do loop diuretics block?
Na/K/2Cl in thick ascending LOH
What diuretics act on DCT?
CA inhibitors
Thiazide diuretics
What do thiazide diuretics block?
Na/Cl in DCT (mild diuresis)
What diuretics act on CD?
K sparing diuretics
What do K sparing agents block?
Na/K in CD
Where on the membrane is the site of action of thiazide, loop and K sparing diuretics?
Apical membrane
= enter from filtrate (apart from spironolactone which enters at basolateral membrane)
Marker for renal plasma flow
PAH (enters at PCT)
OATs
Organic Anion Transporters
Transport acidic drugs (negative), e.g. PAH, thiazides, loop
At PCT
OCTs
Organic Cation Transporters
Transport basic drugs (positive), e.g. triamterene, amiloride
At CD
Na/K/ATPase is always at what membrane:
Basolateral
Maintains low IC Na
Side effects of loop diuretics
Hypokalaemia Hypocalcaemia Hypomagnaesaemia Metabolic alkalosis Hypovolaemia Hyperuricaemia = gout
Additional effect of loop diuretics
Venodilator = good in pulmonary oedema
Indications for loop diuretics
Acute pulmonary oedema Chronic HF Chronic kidney failure Nephrotic syndrome Hepatic cirrhosis AKI Ant-HT Hypercalcaemia (lowers Ca)
Indications for thiazide diuretics
Mild HF HT Severe resistant oedema Kidney stones (reduced urinary Ca excretion) Nephrogenic DI
Side effects of thiazide diuretic
Hypokalaemia Hypomagnaesaemia NOT Ca Hyperuricaemia = gout Metabolic alkalosis Hypovolaemia Male ED Glucose intolerance
How is Na reabsorbed?
At apical membrane by ENaC channel - depends on aldosterone
How does aldosterone help Na reabsorption?
Released in response to AT II
Acts on basolateral membrane to increase synthesis of Na/K channels and ENaC channels
ADH acts via G coupled receptors to:
Increase aquaporins in apical membrane of DCT and CD
How do Amiloride and Triamterene (K sparing) work?
Block ENaC = decreased Na reabsorption in CD, decreased K efflux