Biochemistry Flashcards
1
Q
How do you assess glomerular function?
A
GFR
Proteinuria
2
Q
Ideal GFR marker
A
Appear at constant rate Freely filtered Not secreted Not reabsorbed No extra-renal elimination Endogenous and easy to measure
3
Q
Inulin
A
Appears at constant rate Freely filtered Not secreted Not reabsorbed No extra-renal elimination NOT endogenous NOT easy to measure
4
Q
Urea
A
Does NOT appear at constant rate Freely filtered NOT secreted Reabsorbed Extra-renal elimination Endogenous and easy to measure
5
Q
Where does urea cycle occur?
A
In liver
End product of protein metabolism
6
Q
How is urea excreted?
A
3/4 by kidneys
1/4 extra-renal
7
Q
Creatinine
A
Appears at constant rate Freely filtered Secreted Not reabsorbed No extra-renal elimination Endogneous and easy to measure
8
Q
Serum creatinine confounders
A
Age
Sex
Muscle mass
Diet
9
Q
Clearance
A
Volume of plasma cleared of a substance per minute
10
Q
How to calculate clearance?
A
[creatinine]urine x urine volume / [creatinine]serum x duration of collection
11
Q
How much protein indicates significant glomerular damage?
A
Over 150mg/day
12
Q
Overflow
A
Bence Jones proteins
13
Q
Glomerular
A
Albuminuria
14
Q
Tubular
A
Microglobulinuria
15
Q
Secreted
A
Tamm-Horsfall proteinuria
