Pharmacology Flashcards
the _______ of the drug is plotted where the dose is increasing sharply
therapeutic range
the ________ of a drug may exhibit is plotted where the curve plateaus
maximum response
a function of the amount of a drug to produce an effect
potency
the potency is _____ when the dose is smaller
greater
maximum intensity of effect or response that can be produced by the drug regardless of dose
efficacy
what happens when you administer more of a drug? - more or less chance of adverse effects? more or less efficacy?
same efficacy, more chance of adverse effects
half life is related to what?
duration of effect
the length of drugs effect
duration
the time it takes for the drug to have an effect
onset
placed directly into the GI tract by oral or rectal administration
enteral
drug bypasses GI tract, includes injection, inhalation, and topical
parenteral
considered safest, least expensive, and most convenient drug administration
oral route
largest area of absorption
small intestine
drugs with high first pass effect needs smaller or larger dose
larger
drug blood levels are less predictable for which drug administration
oral
are drugs absorbed well or poorly rectally?
poorly and irregularly
produces most rapid drug response, absorption phase is bypassed, more predictable response, drug irretrievability, allergy, local irritation
IV route
absorption occurs due to high blood flow in skeletal mm, useful for sustained effect, massage increases absorption
IM route
places for IM injections
deltoid or gluteal
route used to administer protein products, may produce sterile abscess or hematoma, ex: insulin and LA
Subcutaneous route
provides rapid delivery of drug across large surface area or respiratory mucosa
inhalation route
drug application to body surface, most effective in keratinized tissue, used when local effect is desired, may have systemic uptake
topical
injected into dermis, ex: TB skin test
intradermal route
topical contraindicated when
ulcerated, burned, abraded skin
study of how drug is absorbed, distributed, metabolized, and excreted by the body
pharmacokinetics
readily move across most biological membranes by diffusion (only drugs to pass blood brain barrier)
lipid soluble drugs
transfer of drugs from site of administration to blood stream
absorption
absorption depends on what factors
drug solubility, circulation at deposition site, surface area, drug pH, temp at site, mechanical factors (massaging injection site)
process b which a drug reversibly leaves the blood stream and enters system
distribution
after being absorbed, drugs go where?
organ with highest blood flow,
oral- liver
sublingual- heart
distribution dependent on what?
blood flow, capillary permeability (blood brain barrier), binding drugs to protein
an abundant plasma protein that binds to a remarkably wide range of drugs
plasma albumin
major site for drug metabolism
liver
does elimination terminate drugs effect?
yes
drugs are most often eliminated by biotransformation or excretion to where
urine or bile
what excretion is most important?
renal
routes of excretion
renal, liver, lungs, bile, GI, sweat, milk, exhalation, saliva, ging crevicular fluid
drugs may be excreted or unchanged as
metabolites
major route of Fl elimination
excretion in urine
factors that alter drug effects
pt compliance, physiological factors, tolerance, pathologic state, time of administration, route of administration, sex, genetic variation, drug interactions, environment, age/weight
amount of desired effect is excessive, dose relation
toxic reaction
dose related reaction that is not part of the desired therapeutic outcome, non therapeutic action of drug such as the drowsiness that occurs with antihistamine use
side effect
abnormal drug response that is usually genetically related
idiosyncratic reaction
hypersensitivy response to a drug to which the pt has been previously exposed, not dose related!
drug allergy
casual relationship between maternal drug use and congenital abnormalities
ex: thalidomide induction fo phocomelia (shortened limbs)
teratogenic effects
local tissue irritation, ex: necrosis at site of injection
local effect
effect of one drug is altered by another
drug interactions
immune hypersensitivity reaction, mild or life threatening
allergic reactions
tx of mild allergic reactions
antihistamine with to w/ out steroids
tx of anaphylactic reaction
epi SQ w/ or w/ out steroids
meds for ging enlargement
phenytoin, cyclosporine, CCBs (nifedipine, verapamil, amlodipine)
ging overgrowth associated with phenytoin generally occurs where
ant facial region
do digoxin, beta blockers, and tegretol cause ging overgrowth?
no
ANS system controls what?
automatic, involuntary responses
ANS responsible for
BP, HR, GI motility, salivation, bronchial/smooth mm tone
two divisions of ANS
parasympathetic and sympathetic
NTM for rest and digest system
ACH
used to mimic the effects of the PNS, also known as cholinergic agents or muscarinic drugs
parasympathomimetics
parasympathomimetics used to tx what?
xerostomia, urinary retention, glaucoma
cholinergic agents derived from plant alkaloids
pilocarpine- stimulates saliva
nicotine
contraindications for parasympathomimetics
asthma, peptic ulcer, cardiac disease, GI/urinary obstruction
inhibits ACH effects by blocking ACH receptors
anticholinergic agents
examples of anticholinergics
atropine, immodium, scopolamine
prototype of anticholinergic, use pre-op to decrease salivary flow in dental setting
atropine
used for motion sickness, anticholinergic
scopolamine
SNS NTM
NE
sympathomimetics, or adrenergic agents, mimic effects of SNS
epi, albuterol, ritalin, adderal, dopamine, clonidine (opiate and benzo withdrawal)
adverse effects of adrenergic agents
CNS disturbances (anxiety, fear, tension, headache, tremor), cardiac arrhythmias, cerebral hemorrhage, pulmonary edema
contraindications for sympathomimetics
angina, uncontrolled hypertension/hyperthyroidism
beta receptor located mainly in heart
beta 1
beta receptor located all over body, but mainly in lungs
beta 2
action of beta 1 receptors
increase heart rate/bp, heart needs more O2
prototype of nonselective b-adrenergic blockers, lowers BP by lowering CO, adverse reactions- bronchoconstriction, arrhythmias
propranolol
reduces aqueous humor in the eye, used topically in the tx of glaucoma
timolol (timoptol, timoptic)
cardioselective b-blocker, eliminates bronchoconstrictor effect, used in tx of hypertensive asthmatic pts
atenolol
cardioselective beta blocker, used for hypertension, prevention of MI and angina
metroprolol (lopressor)
limit epi containing LA to ___ carpules in pts taking non selective beta blockers due to potential increase in BP
2
prototype of non-narcotic analgesias, considered a NSAID, analgesia, antipyretic, anti-inflammator, inhibits PG synthesis, fever reduced through action on hypothalamus
aspirin
side effects of aspirin
interferes with clotting, GI irritation, hypersensitivity, Reye’s syndrome, toxicity (salicylism)
symptoms of aspirin toxicity
GI upset, vomiting, dim vision, tinnitus, coma, respiratory and metabolic acidosis, death from respiratory failure
Considered a NSAID, inhibits PG synthesis, analgesic, antipyretic, anti-inflammatory, side effects- interferes with clothing, GI irritation
Ibuprofen (advil, motrin, nuprin)
can you take ibuprofen with aspirin?
no