Pharmacology Flashcards

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1
Q

how medications move into, through, and out of the body and Affects duration, intensity of the medication’s effects

A

Pharmacokinetics

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2
Q

how the medication acts once it is inside the body and why specific dosages produce specific effects

A

Pharmacodynamics

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3
Q

Pharmacokinetics

A
  • Absorption
  • Distribution
  • Metabolism (biotransformation)
  • Elimination
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4
Q

Absorption is Affected by:

A

*Site/route (blood supply, surface area)
* Concentration
* Solubility
* pH
* Bioavailability (extent and rate)

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5
Q

Absorption is

A

”Pharmaceutical/dosage form” to biologically available substance

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6
Q

Distribution is

A

Transport from site of absorption to site of action.

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7
Q

Distribution is affected by

A
  • Cardiovascular function (shock)
  • Regional blood flow/lack of blood flow
  • Storage reservoirs
  • Plasma protein binding?
  • Physiological barriers
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8
Q

Metabolism types for drugs

A
  • Inactive metabolite
  • Active metabolite
  • More active
  • Less active

-Pro-drug to Active drug (need to be metabolized before doing anything)

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9
Q

What is the main action of Alpha 1 receptors?

A

Peripheral vasodilation with some increase in strength of heart contraction (inotropy) and some increase in heart rate (chronotropy)

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10
Q

Which receptor hits the heart the hardest?

A

Beta 1
Increases chronotropy, inotropy and dromotropy (speed of electrical conduction through AV node)

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11
Q

What do beta 2 receptors act on?

A

Relaxes smooth muscle - peripheral vasodilation, bronchodilation

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12
Q

Dopaminergic receptors do what?

A

Vasodilation in the kidneys and mesentery

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13
Q
A
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