PHARMACOLOGY

Question 1

what parts of the body does oral drug absorption involve

Answer 1

the gastrointestinal tract and the liver

Question 2

what does first pass mtabolism involve

Answer 2

the liver

Question 3

what is bioavailabilty

Answer 3

the fraction of a dose reaching the systemic circulation after oral dosing

Question 4

what does first pass metabolism mean

Answer 4

refers to the amount of drug which is metabolised on its first pass through the liver

Question 5

what is a ligand

Answer 5

something that binds to a biological target

Question 6

what is an endogenous ligand

Answer 6

a natural chemical produced by the body to bind to the biological target

Question 7

what is a drug

Answer 7

an exogenous liana that generates a physiological response

Question 8

what do acidic drugs mainly bind to

Answer 8

bind mainly to albumin

Question 9

what do basic drugs mainly bind to

Answer 9

to alpha-1 acid glycolprotein

Question 10

what is the purpose of protein binding

Answer 10

to reduce the clearance of the drug from the body and enhancing the duration of its action

Question 11

what happens to the protein bound protein once it leaves circulation

Answer 11

it is unbound so that its molecular weight decreases and it can then be removed by the kidneys