Pharmacology 1

Question 1

Define receptors.

Answer 1

Enable specify and mean that the response evoked is also specific.

Question 2

Define steroid hormones.

Answer 2

Lipid soluble and bind to intracellular receptors to alter the rate of transcription.

Question 3

What does NO do with intracellular receptors?

Answer 3

It binds to soluble guanylyl cyclase and generates cGMP as as 2nd messenger which regulates cell activity.

Question 4

What are the 4 types of plasma membrane receptors and their functions?

Answer 4

Ion channels - Ionotropic receptors -> Fast EPSPs/IPSPs
Intrinsic enzyme activity - receptor tyrosine kinases -> proliferation or differentiation
JAK kinases - -> protein synthesis
G-proteins - Biggest group with several sub families.

Question 5

Define G-proteins.

Answer 5

Made up of 3 subunits and when activated the alpha g-protein subunit goes and regulates activity. It is one big amino acid chain with 7 hydrophobic loops.

Question 6

Name 3 G-Protein Coupled Receptors

Answer 6

Adenylyl Cyclase - activates/inhibits PKA
Phospholipase C - produces diacylglycerol
Ion channels - Evoke slow EPSPs/IPSPs

Question 7

Where can calcium be sourced from to be a 2nd messenger?

Answer 7

Internal stores
Voltage/ligand gated channels
Inhibition of calcium channels