Pharmacokinetics

Question 0

(2011)
Explain the concept of compartment model for intravenous drug administration to achieve an effect site target concentration. Use a bolus dose of fentanyl to achieve the target concentration of 3ng/ml for intubation as an example.

Answer 0

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Question 1

(2012)
What are the factors that determine drug clearance? Describe how these factors might change in a patient with congestive heart failure.

Answer 1

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Question 2

(2009)

Describe the effect of obesity on pharmacokinetics and the potential clinical implications, providing relevant examples.

Answer 2

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Question 3

(2009)
What is bioavailability? Briefly describe the factors that determine bioavailability. How do you measure bioavailability?

Answer 3

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Question 4

(2007)
Define pharmacogenomics. Describe the polymorphism of Phase 1 oxidative enzymes giving some examples of altered drug efficacy or toxicity.

Answer 4

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Question 5

(2001/05)

Describe drug protein binding and outline its significance.

Answer 5

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Question 6

(2005)
Outline the factors that determine the offset or recovery after stopping a drug infusion. Explain the importance of T1/2 of a drug.

Answer 6

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Question 7

(2003)
Outline the factors determining transdermal uptake of drugs, giving examples and advantages and disadvantages of this route.

Answer 7

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Question 8

(2003)

Classify esterases and provide examples of their roles in the breakdown of drugs used in anaesthesia.

Answer 8

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Question 9

(Additional)

Explain the mechanism behind interindividual variability in drug responses with particular reference to the elderly.

Answer 9

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