Local Anaesthetics

Question 0

(2010)
Describe briefly the physical and patient factors which can alter the pharmacokinetics of lignocaine thereby altering its clinical effect.

Answer 0

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Question 1

(2011)

Compare and contrast the potential cardiac and vascular effects of lignocaine, bupivacaine and ropivacaine.

Answer 1

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Question 2

(2001/09)

Briefly describe the factors that would prolong the duration of action of local anaesthetic drugs.

Answer 2

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Question 3

(2007)
List some examples of aminoester-linked local anaesthetics. What are the main limitations of these drugs? What determines the state of the amine terminal of the molecule?

Answer 3

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Question 4

(2007)

Outline the deposition of bupivacaine when injected into the lumbar epidural space.

Answer 4

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Question 5

(2006)
Briefly describe the mode of action of drugs used to enhance or prolong the effects of epidural or intrathecal local anaesthetics.

Answer 5

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Question 6

(2004)
How do the physicochemical properties of local anaesthetics relate to their potency, speed of onset and duration of action?

Answer 6

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