Pharmacokinetics

Question 1

a drugs journey through the body is …

Answer 1

pharmacokinetics

Question 2

ability of drug or substance to be absorbed or used by the body

Answer 2

bioavailability

Question 3

What influences the absorption of the drug?

Answer 3

The route of administration

Question 4

phenomenon in which drugs given PO decreases the active drug’s concentration before reaching systemic circulation or its site of action.N

Answer 4

first pass effect

Question 5

movement of a drug to body tissues; depends on blood circulation & plasma protein binding in body

Answer 5

distribution

Question 6

Albumin levels are indicative of …

Answer 6

protein

Question 7

What is required for meds to distributed effectively?

Answer 7

Drugs need to be able to to protein/ Albumin

Question 8

What kind of drugs can pass blood brain barriers?

Answer 8

Only lipid solusble drugs can cross blood brain brain barrier

Question 9

occurs primarily in liver; process in which medication is broken down

Answer 9

Metabolism/ Biotransformation

Question 10

Best way to admin meds to someone who suffers w/ reduced liver function

Answer 10

Bypass GI system by using different route to administer drug (all other routes except PO)

Question 11

process in which meds is eliminated through the body;

Answer 11

Excretion

Question 12

How does poor kidney fx effect pt?

Answer 12

Causes build up of med since it cannot be easily excreted leading to toxicity.

Question 13

method in which drug is entered in to the body

Answer 13

absorption

Question 14

Routes of Admin

Answer 14

PO
IV
IM
SQ
Inhalation
Rectally (PR)
Sublingual
Topical/Transdermal

Question 15

Why is route important?

Answer 15

Due to monitoring for effects of drug

Question 16

How do drugs get into the cell?
3 Methods

Answer 16

-Passive transport DIFFUSION (high conc to low conc)
- Active Transport (low conc to high conc)
Filtration (movement thru membrane either down conc gradient or pull from plasma proteins)

Question 17

Most drugs move through which method into cell?

Answer 17

Diffusion/Passive Transport

Question 18

Poor functioning heart does not effect distribution. T or F

Answer 18

False- Meds will not distribute well as BLOOD CIRCULATION IS MOST IMPORTANT FACTOR IN DISTRIBUTION. Blood doesnt circulate well with a poor functioning heart

Question 19

Anything can pass through placenta/ breast milk. T or F

Answer 19

True

Question 20

Effects of enzyme induction

Answer 20

May speed/ slow metabolism of another drug; either therapeutic effect wont be reached; OR causes toxicity some drugs simply cannot be taken together

Question 21

A drug continues to act in body until its expelled or excreted. T or F

Answer 21

True

Question 22

routes of excretion

Answer 22

KIDNEY *90-95 %
Exocrine glands
lungs
liver
intestines

Question 23

Diseases of heart , liver and kidney effect drug administration. T or F

Answer 23

True

Question 24

Factors that effect drug actions

Answer 24

Age
Weight
Sex
Physiological
Pathological (Diseases/ Allergies)
Environment (hot and cold cant effect peripheral vascular)
Genetic
Drug Related / Tolerance
Drug- FOod Interactions
Drug- Drug Interactions
Level of Blood Albumin

Question 25

when a drug is taken in successive doses if the body is unable to eliminate a drug properly, the drug can build up in the body, leading to toxic levels and adverse effects

Answer 25

accumulation