Pharmacodynamics 4 Flashcards
1
Q
Receptor subtypes
A
Drugs can have different Kd values at each subtype
2
Q
Specific vs selective
A
Most drugs are selective - bind more than one receptor class Specific would bind only one receptor
3
Q
Effect of drugs in patients is dependent on
A
Kd and dose
4
Q
Epinephrine example
A
Higher affinity for Beta 2 but binds otheras
5
Q
Factors that determien toxic effects
A
Excessive activation of target receptors or activation of other receptors
6
Q
Therapeutic window
A
DIfferent between toxic and therapeutic effect
7
Q
Therapeutic index
A
TI=LD50/ED50
Higher TI means safer drug
