Pharmacodynamics 1

Question 1

Drug

Answer 1

Can be naturally occurring or synthetic organic molecule that acts with a receptor to produce physiologic effect

Also antibodies or vaccines

Question 2

Receptor

Answer 2

Any macromolecule to which an NT or drug binds to initiate effects…function is in neurotransmission of physiologic regulation

Question 3

Examples of Ion channel drugs

Answer 3

Calcium channel blockers, anti-arrythmic drugs, local anesthetics

Question 4

GPCRs

Answer 4

On cell surface….where norep and epi act…activates 2ndary messenger

Question 5

Tyrosine kinase

Answer 5

Dimerize and autophosphorylate…lots of cancer drugs

Question 6

Steroid hormones

Answer 6

Agonist receptor complex moves to the nucleus and changes protein synthesis

Question 7

Some receptors

Answer 7

Don’t need anything to bind

Question 8

Affinity

Answer 8

Determines the binding to the receptor
Electrostatic forces
Measure of strength that a durg binds to receptor

Question 9

Structural differences will

Answer 9

Result in differences in receptor affinity

Question 10

Affinity equation

Answer 10

K1/K-1
(DR)/(D*R)

K1 = rate of association 
K-1 = rate of dissociation 

Higher number = higher affinity

Question 11

Kd equation

Answer 11

Kd = K-1/K1
= (D*R)/(DR)
= 1/affinity

Equilibrium dissociation constant

Question 12

Kd units and that it means

Answer 12

Concentration

Concentration of a drug that will occupy 50% of the total receptor population

Question 13

SMaller Kds will

Answer 13

Bind tighter to the receptor

Means that you would need a smaller concentration of the drug to bind to half of the receptors