Pharmacodynamics 3

Question 1

Competitive antagonists

Answer 1

Bind in reversible manner to the receptor to block agonist action

Question 2

Competitive antagonists shift curve

Answer 2

To the right without shifting the maximum response

Will not change the maximum

Can overcome with more agonist

Question 3

Partial agonists as an antagonist

Answer 3

Can block action of a full agonist by taking up receptor binding sites

Question 4

Irreversible antagonists

Answer 4

Bind to receptor and then covalently link

Question 5

Irreversible antagonists shift curve

Answer 5

Lower max and shift to the right

Cannot be overcome with more agonist

Question 6

Constitutively active receptors

Answer 6

Under certain conditions, receptor can assume active conformation in absence of activting ligand

Question 7

Cause of constitutively active receptors

Answer 7

Genetic mutations that cause loss of control by regulators

Question 8

Inverse agonism

Answer 8

Inverse agonist binds to constiutively actie receptor, decreasing the receptor activation